Gamma-secretase Inhibitors
Items 11 to 18 of 18 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BMS 299897 | 290315-45-6 | sc-358829 | 25 mg | $265.00 | 1 | |
BMS 299897 acts as a potent gamma-secretase inhibitor, characterized by its ability to disrupt the enzyme's substrate processing through specific interactions with the catalytic site. This compound exhibits a unique mechanism of action, where it stabilizes an inactive conformation of the enzyme, thereby reducing substrate affinity. Its structural features promote selective binding, influencing the enzyme's reaction kinetics and altering the pathway of amyloid precursor protein cleavage. | ||||||
Semagacestat | 425386-60-3 | sc-364614 sc-364614A | 10 mg 50 mg | $350.00 $1200.00 | 1 | |
Semagacestat functions as a selective gamma-secretase modulator, exhibiting unique binding dynamics that alter the enzyme's conformational landscape. By engaging with specific allosteric sites, it influences the enzyme's activity without fully inhibiting it. This modulation leads to distinct changes in substrate processing pathways, affecting the cleavage of various substrates. Its kinetic profile reveals a nuanced interaction that fine-tunes the enzyme's function, showcasing its potential to shift the balance of proteolytic activity. | ||||||
γ-Secretase Inhibitor XI | sc-222305 | 5 mg | $218.00 | |||
γ-Secretase Inhibitor XI operates by selectively disrupting the gamma-secretase complex, targeting its active site to impede substrate cleavage. This compound exhibits a unique affinity for the enzyme, leading to altered reaction kinetics that slow down the processing of amyloid precursor proteins. Its distinct molecular interactions can induce conformational changes, ultimately affecting the enzyme's overall stability and functionality, thereby influencing the proteolytic landscape in a targeted manner. | ||||||
Compound W | 173550-33-9 | sc-202553 | 100 mg | $138.00 | ||
Compound W functions as a gamma-secretase modulator by engaging with the enzyme's allosteric sites, which leads to nuanced alterations in substrate recognition and processing. This compound exhibits a unique binding profile that stabilizes specific conformations of the enzyme, thereby fine-tuning its catalytic activity. The resulting changes in reaction kinetics can shift the balance of proteolytic products, impacting cellular signaling pathways and protein interactions in a selective manner. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
Dibenzazepine acts as a gamma-secretase modulator by selectively interacting with the enzyme's active site, influencing substrate affinity and processing dynamics. Its unique structural features allow for the modulation of enzyme conformations, which can enhance or inhibit catalytic efficiency. This compound's distinct binding characteristics lead to altered proteolytic outcomes, thereby affecting downstream signaling cascades and cellular communication in a targeted fashion. | ||||||
L-685,458 | 292632-98-5 | sc-204042 sc-204042A | 1 mg 5 mg | $337.00 $1000.00 | 4 | |
L-685,458 functions as a gamma-secretase modulator by engaging with specific allosteric sites on the enzyme, thereby altering its conformational landscape. This compound exhibits unique binding kinetics, which can stabilize or destabilize enzyme-substrate complexes, influencing the rate of substrate cleavage. Its distinct molecular interactions can lead to differential modulation of substrate processing, impacting the overall enzymatic activity and subsequent cellular pathways. | ||||||
γ-Secretase Inhibitor VII | sc-301797 sc-301797A | 1 mg 5 mg | $160.00 $700.00 | |||
γ-Secretase Inhibitor VII operates by selectively binding to the active site of gamma-secretase, disrupting its proteolytic function. This compound exhibits a unique affinity for the enzyme, leading to altered substrate recognition and processing dynamics. Its interaction profile suggests a competitive inhibition mechanism, which can significantly affect the cleavage of transmembrane proteins. The inhibitor's structural characteristics facilitate specific molecular interactions that modulate the enzyme's catalytic efficiency and influence downstream signaling pathways. | ||||||
Compound 34 | sc-391108 sc-391108A | 200 µg 1 mg | $82.00 $265.00 | 3 | ||
Compound 34 functions as a gamma-secretase modulator, exhibiting a distinctive mechanism of action through allosteric regulation. By binding to an alternative site on the enzyme, it induces conformational changes that enhance substrate affinity while simultaneously altering the cleavage specificity. This compound's kinetic profile reveals a unique interaction with the enzyme's active site, leading to a nuanced modulation of proteolytic activity and influencing the dynamics of cellular signaling cascades. | ||||||