galectin-16 Inhibitors
Galectin-16 inhibitors encompass a range of compounds that interact with the carbohydrate recognition domain (CRD) of the protein or affect the glycosylation status of its ligands. Lactose and galactose, for example, function as competitive inhibitors by directly occupying the CRD of galectin-16, which inhibits the protein's ability to bind to its physiological targets on cell surfaces. This inhibition can disrupt cell-cell and cell-matrix interactions that are crucial for numerous cellular processes. Methyl-β-D-galactopyranoside and thiodigalactoside also act as direct inhibitors by mimicking the structure of galactose residues, thus competitively inhibiting the interaction of galectin-16 with its natural ligands. Phenyl-β-D-galactopyranoside operates similarly, binding to the CRD and impeding galectin-16 mediated signaling and immune functions.
The functional mechanisms of galectin-16 inhibitors also include compounds that indirectly affect the protein's activityby modifying the glycosylation status of cellular proteins. Castanospermine and swainsonine inhibit glycosidase enzymes, leading to the accumulation of glycoproteins with high mannose content, which can sequester galectin-16 and prevent it from interacting with its normal binding partners. Deoxynojirimycin and deoxymannojirimycin, both iminosugars, inhibit glycosidases as well, resulting in the misfolding of N-linked glycoproteins. This aberrant glycosylation increases the affinity of these proteins for galectin-16, thus reducing its functional availability. Fucoidan, by acting as a decoy substrate, can bind to galectin-16 and inhibit its role in physiological processes like cell adhesion and migration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lactose | 63-42-3 | sc-221828A sc-221828 sc-221828B | 500 g 1 kg 2.5 kg | $107.00 $157.00 $345.00 | 1 | |
Lactose, a disaccharide, can competitively inhibit galectin-16 by binding to its carbohydrate recognition domains. This binding prevents galectin-16 from interacting with its natural glycoprotein targets, thus inhibiting its functional activity in cell adhesion processes. | ||||||
D-Galactose | 59-23-4 | sc-202564 | 100 g | $224.00 | 4 | |
Galactose can bind to the carbohydrate recognition domain of galectin-16, inhibiting its ability to interact with glycoconjugates on the cell surface, which impairs cell-cell and cell-matrix interactions mediated by galectin-16. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
An indolizidine alkaloid that inhibits glucosidase enzymes, castanospermine indirectly inhibits galectin-16 by increasing the levels of high-mannose glycoproteins, which may bind and sequester galectin-16 away from its functional targets. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $135.00 $246.00 $619.00 $799.00 $1796.00 | 6 | |
An inhibitor of α-mannosidase II, swainsonine leads to the accumulation of misfolded glycoproteins, which may preferentially bind to galectin-16, reducing its availability to interact with normal binding partners and thus inhibiting its function. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $72.00 $142.00 | ||
As an iminosugar and an inhibitor of glucosidases, deoxynojirimycin promotes the misfolding of N-linked glycoproteins. This increases their affinity for galectin-16, sequestering it and inhibiting its biological activity. | ||||||
Deoxymannojirimycin hydrochloride | 84444-90-6 | sc-201360 sc-201360A | 1 mg 5 mg | $93.00 $239.00 | 2 | |
Similar to deoxynojirimycin, this iminosugar inhibits mannosidase, causing a build-up of high mannose-type glycoproteins. These bind to galectin-16, effectively inhibiting its normal functional interactions. | ||||||
Fucoidan | 9072-19-9 | sc-255187 sc-255187A | 5 g 10 g | $186.00 $312.00 | 7 | |
A sulfated polysaccharide that binds to various galectins, fucoidan can inhibit galectin-16 by acting as a decoy substrate, thus disrupting its involvement in cell adhesion and migration. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, and it can indirectly inhibit galectin-16 by altering the glycosylation pattern of cellular proteins, which affects galectin-16's ability to recognize and bind its ligands effectively. | ||||||