GADD 45 Activators
GADD45 Activators encompass a diverse array of chemical compounds that indirectly enhance the functional activity of GADD45 through various specific signaling pathways or biological processes. Spermine, curcumin, resveratrol, sulforaphane, and vitamin D3 all serve as activators of GADD45 by influencing distinct pathways that converge on the stress response and DNA repair mechanisms, which are central to GADD45's role. Spermine, by altering ROS levels, and curcumin, through modulation of the NF-κB pathway, both potentiate GADD45's involvement in managing cellular stress. Resveratrol's activation of SIRT1 and sulforaphane's impact on the Keap1-Nrf2 pathway further enable GADD45 to execute its function in DNA damage response and cell cycle regulation. Vitamin D3 operates through the VDR pathway, reinforcing GADD45's engagement in DNA repair processes.
Additionally, zinc ions, arsenic trioxide, quercetin, EGCG, melatonin, omega-3 fatty acids, and lithium are all implicated in the activation of GADD45 by targeting various cellular processes that GADD45 is directly involved in.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can directly enhance the activity of GADD45 by modulating the intracellular levels of reactive oxygen species (ROS), which affects cellular stress responses that GADD45 is involved in. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound that can activate GADD45 by modulating the NF-κB pathway, which is known to be involved in cellular stress response mechanisms that intersect with GADD45 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can enhance the function of GADD45 by activating the SIRT1 pathway, which is involved in the DNA damage response and cell cycle control, both processes where GADD45 plays a critical role. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates GADD45 by influencing the Keap1-Nrf2 pathway, leading to the induction of antioxidant response element-driven genes, a process in which GADD45 is implicated. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 enhances GADD45 activity by modulating the VDR pathway, which intersects with DNA repair and cell cycle control systems involving GADD45. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can activate GADD45 by stabilizing the protein structure and promoting its interaction with other molecules in the MAPK pathway, which is critical for the cellular stress response. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic Trioxide enhances GADD45 activity by inducing oxidative stress, which activates the GADD45-involved stress response pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin enhances the function of GADD45 through its role as an antioxidant, modulating cellular redox states and thereby influencing stress-related pathways in which GADD45 is active. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates GADD45 by inhibiting DNA methyltransferases, leading to demethylation of the GADD45 gene and enhanced gene expression, indirectly increasing the protein's functional activity. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
Melatonin enhances the activity of GADD45 by modulating circadian rhythms, which are known to influence the cell cycle and DNA damage response pathways where GADD45 is involved. | ||||||