Date published: 2025-10-24

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FTβ Activators

FNTB activators are a unique class of compounds that can enhance the functionality of Farnesyltransferase Beta (FNTB), a protein subunit that plays a pivotal role in the post-translational modification of other proteins. This protein is a critical component of the farnesyltransferase complex, which adds a farnesyl group to specific proteins, a process known as farnesylation. Farnesylation can influence protein function, localization, and interactions, and FNTB is integral to this process. The group of activators associated with FNTB includes both direct substrates for farnesyltransferase and precursor molecules involved in the farnesylation process. Farnesyl pyrophosphate, for instance, is a direct substrate of farnesyltransferase. It provides the farnesyl group that FNTB transfers to target proteins.

The same is true for geranylgeranyl pyrophosphate, another substrate for farnesyltransferase. By providing the farnesyl group for transfer, these compounds can directly amplify the functional activity of FNTB. On the other hand, compounds such as isopentenyl pyrophosphate and dimethylallyl pyrophosphate are precursor molecules in the synthesis of farnesyl pyrophosphate. An increase in the availability of these precursors can indirectly enhance the functional activity of FNTB by increasing the production of farnesyl pyrophosphate. Acetyl-CoA and 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA), are examples of precursors in the mevalonate pathway, which results in the production of farnesyl pyrophosphate. Their presence can indirectly enhance the functional activity of FNTB by increasing the production of farnesyl pyrophosphate. Similarly, compounds like squalene, geraniol, and farnesol, which are part of the biosynthetic pathway leading to the production of farnesyl pyrophosphate, can also work to enhance FNTB's functionality by increasing the availability of farnesyl pyrophosphate. Each of these activators, through their unique mechanisms, serve to facilitate the critical role FNTB plays in protein farnesylation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Geranylgeranylpyrophosphate triammonium salt

6699-20-3sc-200849
200 µg
$120.00
(1)

Geranylgeranyl pyrophosphate is a critical substrate for farnesyltransferase, including FNTB. It provides the farnesyl group that FNTB helps to transfer to target proteins, enhancing the functional activity of FNTB.

Farnesyl pyrophosphate ammonium salt

13058-04-3sc-200847
sc-200847A
1 mg
5 mg
$469.00
$1938.00
(1)

Farnesyl pyrophosphate is the direct substrate for farnesyltransferase, including FNTB. It provides the farnesyl group that FNTB transfers to target proteins, thus enhancing the functional activity of FNTB.

Squalene

111-02-4sc-281155
sc-281155A
sc-281155B
10 ml
100 ml
500 ml
$48.00
$90.00
$211.00
1
(0)

Squalene is part of the biosynthetic pathway leading to the production of farnesyl pyrophosphate. Its presence can indirectly enhance the functional activity of FNTB by increasing the availability of farnesyl pyrophosphate.

Geraniol

106-24-1sc-235242
sc-235242A
25 g
100 g
$44.00
$117.00
(0)

Geraniol is part of the biosynthetic pathway leading to the production of farnesyl pyrophosphate. Its presence can indirectly enhance the functional activity of FNTB by increasing the availability of farnesyl pyrophosphate.

Farnesol

4602-84-0sc-204748
sc-204748A
50 ml
100 ml
$275.00
$367.00
2
(1)

Farnesol is part of the biosynthetic pathway leading to the production of farnesyl pyrophosphate. Its presence can indirectly enhance the functional activity of FNTB by increasing the availability of farnesyl pyrophosphate.