FMO2 Activators
FMO2 activators encompass a diverse range of chemical compounds, primarily involving drugs that undergo metabolism via FMO2. These compounds, through their interaction with FMO2, lead to an enhancement of its functional activity, particularly in drug metabolism and biotransformation. Sulindac Sulfide, Benzydamine, and Clozapine are notable examples where their metabolism by FMO2 results in the production of specific metabolites like N-oxides and reactive intermediates. This metabolic interaction indicates a direct role of FMO2 in their biotransformation, leading to an increase in enzyme activity.
Similarly, the metabolism of Nicotine, Omeprazole, Ketoconazole, Cimetidine, Ranitidine, Tamoxifen, Indomethacin, and Tizanidine by FMO2 enhances the enzyme's role in the metabolism of these diverse compounds. The functional mechanisms of FMO2 activation by these compounds are characterized by their substrate-specific interactions with the enzyme, leading to altered drug metabolism pathways. The involvement of FMO2 in the N-oxidation of several of these drugs highlights its significant role in the oxidative metabolism of xenobiotics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac Sulfide, a non-steroidal anti-inflammatory drug (NSAID), is metabolized by FMO enzymes. Its metabolism through FMO2 can lead to the production of reactive metabolites, which can enhance the functional activity of FMO2 in drug metabolism. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A | 50 mg 500 mg | $68.00 $357.00 | 11 | |
Clozapine, an antipsychotic agent in research, undergoes N-oxidation primarily through FMOs. Its interaction with FMO2 can lead to the formation of Clozapine N-oxide, enhancing FMO2's role in drug metabolism. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole, a proton pump inhibitor, is metabolized by FMOs. The metabolic conversion of Omeprazole by FMO2 could enhance the enzyme's activity in drug metabolism, particularly in the formation of sulfone metabolites. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole, an antifungal agent, undergoes metabolism by FMOs. This interaction with FMO2 can lead to altered drug metabolism, potentially enhancing FMO2's functional activity. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine, a histamine H2 receptor antagonist, is metabolized by FMOs. FMO2's involvement in the N-oxidation of Cimetidine can lead to increased enzyme activity and drug metabolism. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $189.00 | ||
Ranitidine, another H2 receptor antagonist, undergoes metabolism through FMOs. FMO2's role in Ranitidine metabolism could enhance its functional activity in drug biotransformation. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen, a selective estrogen receptor modulator, is metabolized by various enzymes including FMOs. Metabolism by FMO2 can lead to the production of N-oxide metabolites, enhancing the enzyme's activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin, an NSAID, undergoes metabolism by FMOs. FMO2's role in the metabolism of Indomethacin could enhance its activity in drug metabolism. | ||||||