Ferroportin-1 Activators
The class of chemicals known as Ferroportin-1 activators comprises a diverse set of compounds that modulate the activity of Ferroportin-1, a crucial protein involved in cellular iron homeostasis. These activators exert their effects through intricate signaling pathways, influencing Ferroportin-1 expression and function to regulate the export of iron from cells. Hemin, for instance, activates Ferroportin-1 by upregulating heme oxygenase-1 (HO-1), leading to increased heme degradation. This process results in the liberation of iron, which, in turn, activates Ferroportin-1, facilitating the export of iron from cells and contributing to the delicate balance of cellular iron homeostasis. Diflunisal operates by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1), a key player in cellular signaling. This inhibition enhances Ferroportin-1 expression, allowing for increased iron export and playing a pivotal role in the maintenance of cellular iron homeostasis.
AICAR, a potent activator, stimulates AMP-activated protein kinase (AMPK), suppressing mTORC1 and subsequently activating Ferroportin-1. This AMPK-mediated regulation provides a cellular mechanism for controlling iron export and maintaining iron homeostasis. Deferoxamine, on the other hand, operates through chelation, preventing the intracellular accumulation of iron. By binding to iron, Deferoxamine facilitates Ferroportin-1-mediated iron export, contributing to the prevention of iron-induced cellular damage and highlighting its role in cellular iron homeostasis regulation. Piperlongumine adds another dimension by activating Ferroportin-1 through the induction of reactive oxygen species (ROS)-mediated NRF2 activation. This activation enhances Ferroportin-1 expression, promoting iron export and influencing cellular iron homeostasis through the regulation of NRF2-mediated antioxidant responses. Clioquinol, Salinomycin, 6-AN, Ciclopirox, Masitinib, and Sulforaphane each contribute to the class of Ferroportin-1 activators by targeting specific pathways associated with iron metabolism. Whether through Wnt/β-catenin, JAK2/STAT3, HIF-2α, Lyn kinase, or NRF2-mediated signaling, these chemicals exemplify the diverse strategies employed to modulate Ferroportin-1 activity and maintain the delicate balance of cellular iron homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hemin chloride | 16009-13-5 | sc-202646 sc-202646A sc-202646B | 5 g 10 g 25 g | $100.00 $157.00 $320.00 | 9 | |
Hemin activates Ferroportin-1 by upregulating HO-1, leading to increased heme degradation. The resulting release of iron activates Ferroportin-1, promoting iron export from cells and contributing to the regulation of cellular iron homeostasis. | ||||||
Diflunisal | 22494-42-4 | sc-205649 sc-205649A | 5 g 10 g | $39.00 $58.00 | ||
Diflunisal activates Ferroportin-1 by inhibiting mTORC1, suppressing the mTOR pathway. This inhibition enhances Ferroportin-1 expression, facilitating iron export from cells and playing a role in cellular iron balance and iron homeostasis regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin indirectly activates Ferroportin-1 by inhibiting PI3K/Akt/mTOR, influencing mTORC1 activity. This modulation enhances Ferroportin-1 expression, promoting iron export and contributing to cellular iron homeostasis through the regulation of mTOR signaling. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates Ferroportin-1 by stimulating AMPK, suppressing mTORC1. This activation enhances Ferroportin-1 expression, promoting iron export and influencing cellular iron homeostasis through the regulation of AMPK-mediated signaling pathways. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $250.00 | ||
Deferoxamine activates Ferroportin-1 by chelating iron, preventing its intracellular accumulation. This chelation promotes Ferroportin-1-mediated iron export, contributing to the regulation of cellular iron homeostasis and preventing iron-induced cellular damage. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine activates Ferroportin-1 by inducing ROS-mediated NRF2 activation. This activation enhances Ferroportin-1 expression, promoting iron export and influencing cellular iron homeostasis through the regulation of NRF2-mediated antioxidant responses. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Clioquinol activates Ferroportin-1 by chelating intracellular iron, preventing its sequestration. This chelation enhances Ferroportin-1-mediated iron export, contributing to the regulation of cellular iron homeostasis and preventing iron-induced cellular damage. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin activates Ferroportin-1 by inhibiting Wnt/β-catenin signaling. This inhibition enhances Ferroportin-1 expression, promoting iron export and influencing cellular iron homeostasis through the regulation of Wnt/β-catenin-mediated signaling pathways. | ||||||
6-Aminonicotinamide | 329-89-5 | sc-278446 sc-278446A | 1 g 5 g | $153.00 $390.00 | 3 | |
6-AN activates Ferroportin-1 by inhibiting JAK2/STAT3 signaling. This inhibition enhances Ferroportin-1 expression, promoting iron export and influencing cellular iron homeostasis through the regulation of JAK2/STAT3-mediated signaling pathways. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
Ciclopirox activates Ferroportin-1 by inhibiting HIF-2α. This inhibition enhances Ferroportin-1 expression, promoting iron export and influencing cellular iron homeostasis through the regulation of HIF-2α-mediated signaling pathways associated with iron metabolism. | ||||||