FBXW18 Inhibitors

FBXW18, a member of the F-box protein family, plays a crucial role in cellular homeostasis by participating in the regulation of protein turnover. Functionally, FBXW18 operates as a component of the SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complex, contributing to the ubiquitination and subsequent degradation of specific target proteins. The primary function of FBXW18 lies in its ability to recognize substrate proteins and facilitate their ubiquitination, marking them for degradation by the proteasome.

The inhibition of FBXW18 is intricately linked to cellular processes influenced by various signaling pathways and molecular events. FBXW18 targets proteins involved in critical pathways such as the PI3K/Akt, NF-κB, TGF-β/SMAD, and cell cycle regulation. The chemicals listed in the table act as inhibitors either directly or indirectly, disrupting these pathways and leading to the inhibition of FBXW18. For example, AZD-8055 inhibits mTOR, impacting FBXW18 indirectly through the mTOR pathway, while JQ1 modulates transcriptional events, influencing FBXW18 indirectly by altering gene expression patterns. In summary, FBXW18 inhibitors serve as valuable tools for unraveling the intricate network of cellular processes governed by FBXW18. The modulation of FBXW18 activity through these inhibitors provides insights into the regulatory mechanisms orchestrating protein turnover and cellular homeostasis.