FATP4 Activators
Bezafibrate, fenofibrate, and GW7647, all being PPAR agonists, enhance the cellular demand for fatty acid transport by increasing the expression of genes involved in fatty acid oxidation, which would logically necessitate an elevation in FATP4 activity to meet the heightened transport requirements. Similar in function, rosiglitazone and pioglitazone act on PPARγ, promoting lipid storage and adipocyte function, thereby potentially augmenting FATP4's role in shuttling fatty acids into cells for these processes. The AMPK activators, AICAR and berberine, shift cellular energy balance towards catabolic pathways that utilize fatty acids, thus indirectly stimulating FATP4's activity to satisfy the increased demand for intracellular fatty acid transport. L-Carnitine, while its primary function is to escort fatty acids into mitochondria, could indirectly enhance FATP4 activity by raising cellular reliance on fatty acid uptake for mitochondrial β-oxidation.
Continuing this mechanistic exploration, Oleoylethanolamide (OEA), through its agonistic action on PPARα, supports enhanced fatty acid metabolism, which could indirectly lead to increased activity of FATP4 as the cellular demand for fatty acid transport intensifies. Nicotinic Acid and its analog Acipimox, by influencing lipid profiles and fatty acid oxidation through their roles in NAD+ metabolism and reduction of plasma free fatty acids, respectively, can create a scenario in which FATP4 activity is indirectly upregulated to maintain adequate fatty acid uptake. Alpha-lipoic acid, with its metabolic modulation properties, could also necessitate an increase in FATP4 functional activity to support altered fatty acid metabolism. Collectively, these compounds, through their targeted influence on cellular lipid handling and metabolic shifts, provide an environment that would logically necessitate the enhanced activity of FATP4 to meet the metabolic demands of the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate is a fibric acid derivative that activates peroxisome proliferator-activated receptors (PPARs). Activation of PPARs can lead to an upregulation of genes involved in fatty acid oxidation, which may increase the demand for fatty acid transport and indirectly enhance the activity of FATP4. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP analog that activates AMP-activated protein kinase (AMPK). Activation of AMPK shifts cellular energy metabolism towards catabolic processes, including fatty acid oxidation, potentially increasing the functional demand for FATP4 in transporting fatty acids into the cell for this process. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
L-Carnitine facilitates the transport of long-chain fatty acids into mitochondria for β-oxidation. While not directly activating FATP4, increased β-oxidation could create a higher cellular requirement for fatty acid transport, indirectly enhancing FATP4 activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPARγ agonist that modulates lipid metabolism. By activating PPARγ, it may indirectly enhance FATP4 activity by increasing fatty acid uptake and utilization in adipose tissues, which is one of the tissues where FATP4 is expressed. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, like bezafibrate, is a PPARα agonist that increases the expression of genes involved in fatty acid transport and metabolism, possibly leading to an increased functional activity of FATP4 due to elevated fatty acid transport into cells. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
OEA is a naturally occurring ethanolamide lipid that acts as a PPARα agonist. It can enhance fatty acid metabolism, which may indirectly lead to increased activity of FATP4 as the cellular demand for fatty acid transport rises. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647 is a potent PPARα agonist that could increase the expression of proteins involved in fatty acid uptake and metabolism, potentially enhancing the functional activity of FATP4 through increased substrate availability. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist that can enhance adipocyte differentiation and fatty acid storage, indirectly influencing FATP4 activity by modulating the cellular uptake of fatty acids. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic Acid, or niacin, can influence lipid metabolism through its role as a precursor for NAD+, which is essential for various metabolic processes including fatty acid oxidation. An increase in fatty acid oxidation could indirectly require enhanced FATP4 activity for fatty acid transport. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid is an antioxidant that also modulates cellular metabolism and has been shown to influence fatty acid metabolism. This alteration in metabolism could indirectly enhance the functional activity of FATP4 due to increased cellular uptake and utilization of fatty acids. | ||||||