FAM24A Activators
FAM24A activators belong to a category of chemical agents that specifically interact with the protein family member 24A, commonly abbreviated as FAM24A. The FAM24A gene encodes a protein whose precise biological role is not entirely understood, yet it is thought to be involved in various cellular processes. Activators of this protein influence its activity, leading to an upregulation of its function within cells. These chemical activators can be small organic molecules, peptides, or other types of compounds that have been identified to interact either directly with the FAM24A protein or indirectly through modulating the cellular pathways that control its expression and function. The specificity of these activators is of significant interest as they selectively target this particular protein, which is believed to play a role in fundamental cellular mechanisms.
The design and development of FAM24A activators involve intricate biochemical and pharmacological techniques to ensure specificity and effectiveness in modulating the protein's activity. Biochemical assays are commonly employed to measure the activation of FAM24A, which can involve changes in enzymatic activity, alterations in binding affinity to other molecular partners, or variations in the protein's stability and localization within the cell. High-throughput screening methods are often utilized to identify potential activators from large chemical libraries, followed by iterative cycles of optimization to enhance their potency and selectivity. The molecular interaction between FAM24A activators and their target is further elucidated through techniques like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling, which help in understanding the binding modes and conformational changes induced upon activation. This knowledge aids in refining the chemical structure of these activators to achieve the desired level of interaction with the FAM24A protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC can phosphorylate a wide range of substrates, potentially including FAM24A, to modulate its activity directly or regulate proteins that interact with or modulate FAM24A function. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation can lead to phosphorylation and activation of downstream proteins, potentially including FAM24A, thereby enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may phosphorylate FAM24A or associated regulatory proteins, leading to increased activity of FAM24A. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific PKC inhibitor that can indirectly enhance FAM24A activity by reducing PKC-mediated inhibitory phosphorylation of proteins that regulate FAM24A activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit various protein kinases. By inhibiting these kinases, EGCG may reduce negative regulatory phosphorylations and thus enhance the functional activity of proteins such as FAM24A. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs) like JNK. Activation of these kinases can lead to phosphorylation of transcription factors that increase expression of proteins involved in stress responses, potentially including FAM24A. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can modulate various ion channels and may indirectly enhance FAM24A activity by altering cellular ionic balances, which can affect signaling pathways regulating FAM24A. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor which can shift the balance of cellular signaling pathways by inhibiting p38 MAPK, thereby potentially enhancing signaling pathways that activate FAM24A. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that prevents the activation of ERK1/2. This can lead to an upregulation of proteins that are negatively regulated by ERK1/2 signaling, potentially including FAM24A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that reduces AKT signaling, which might result in the activation of compensatory pathways that enhance the functional activity of FAM24A. | ||||||