Date published: 2025-12-24

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FAM120B Inhibitors

Chemical inhibitors of FAM120B target the ubiquitin-proteasome system (UPS) in which this protein is involved, employing a variety of mechanisms to impede the protein's function. Compounds such as MG132, Bortezomib, Lactacystin, Epoxomicin, Withaferin A, Carfilzomib, Oprozomib, Delanzomib, Marizomib, Ixazomib, and Velcade are proteasome inhibitors that function by binding to the proteasomal subunits to prevent the degradation of ubiquitinated proteins. This inhibition can lead to the accumulation of proteins that are normally targeted for degradation, which can disrupt various cellular processes, including those in which FAM120B plays a part. For instance, Bortezomib binds specifically to the 26S proteasome, while Carfilzomib, Oprozomib, Delanzomib, Marizomib, Ixazomib, and Velcade, which is another name for Bortezomib, selectively inhibit the threonine protease activity of the proteasome. These actions can lead to the interruption of the normal turnover of proteins regulated by the UPS, thereby influencing FAM120B's functional role in this pathway. On the other hand, Auranofin inhibits the proteasomal deubiquitinating enzymes. By interfering with deubiquitination, Auranofin can prevent the recycling of ubiquitin, which is a critical molecule for tagging proteins for degradation. Without the proper functioning of deubiquitinating enzymes, proteins that are destined for degradation by the proteasome, which would include those in the functional sphere of FAM120B, can accumulate and disrupt the cellular homeostasis.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

MG132 is a proteasome inhibitor that prevents the degradation of proteins by the ubiquitin-proteasome pathway, thereby inhibiting FAM120B's role in this process.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib specifically inhibits the 26S proteasome, which is involved in the degradation of ubiquitinated proteins, thereby functionally inhibiting FAM120B's associated processes.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

Lactacystin irreversibly binds to and inhibits the proteasome, affecting protein turnover and indirectly inhibiting the function of FAM120B within the protein degradation pathway.

Epoxomicin

134381-21-8sc-201298C
sc-201298
sc-201298A
sc-201298B
50 µg
100 µg
250 µg
500 µg
$134.00
$215.00
$440.00
$496.00
19
(2)

Epoxomicin is a selective proteasome inhibitor, which by preventing proteasomal activity can indirectly inhibit FAM120B's function in protein degradation.

Withaferin A

5119-48-2sc-200381
sc-200381A
sc-200381B
sc-200381C
1 mg
10 mg
100 mg
1 g
$127.00
$572.00
$4090.00
$20104.00
20
(1)

Withaferin A has been shown to disrupt the proteasomal pathway, which would affect the degradation of proteins and thus the function of FAM120B in this pathway.

Carfilzomib

868540-17-4sc-396755
5 mg
$40.00
(0)

Carfilzomib is a selective proteasome inhibitor that would prevent the degradation of proteins through the ubiquitin-proteasome system, indirectly inhibiting FAM120B.

Oprozomib

935888-69-0sc-477447
2.5 mg
$280.00
(0)

Oprozomib inhibits the proteasome, impacting the protein degradation pathway and indirectly the functional role of FAM120B within this system.

Delanzomib, free base

847499-27-8sc-396774
sc-396774A
5 mg
10 mg
$160.00
$300.00
(0)

Delanzomib is a proteasome inhibitor that would affect the protein turnover process, indirectly inhibiting the functional involvement of FAM120B.

Ixazomib

1072833-77-2sc-489103
sc-489103A
10 mg
50 mg
$311.00
$719.00
(0)

Ixazomib inhibits the activity of the proteasome, indirectly inhibiting the function of FAM120B in protein degradation.

Auranofin

34031-32-8sc-202476
sc-202476A
sc-202476B
25 mg
100 mg
2 g
$150.00
$210.00
$1899.00
39
(2)

Auranofin inhibits the proteasomal deubiquitinating enzymes, which would affect protein degradation pathways and could indirectly inhibit FAM120B's function.