FAM120B Inibidores

Os inibidores comuns do FAM120B incluem, entre outros, o MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6, o bortezomib CAS 179324-69-7, a lactacistina CAS 133343-34-7, a epoxomicina CAS 134381-21-8 e a withaferina A CAS 5119-48-2.

Chemical inhibitors of FAM120B target the ubiquitin-proteasome system (UPS) in which this protein is involved, employing a variety of mechanisms to impede the protein's function. Compounds such as MG132, Bortezomib, Lactacystin, Epoxomicin, Withaferin A, Carfilzomib, Oprozomib, Delanzomib, Marizomib, Ixazomib and Velcade are proteasome inhibitors that work by protein binding to proteasomal subunits to prevent the degradation of ubiquitinated proteins. This inhibition can lead to the accumulation of proteins that are normally targeted for degradation, which can disrupt various cellular processes, including those in which FAM120B plays a role. For example, Bortezomib binds specifically to the 26S proteasome, while Carfilzomib, Oprozomib, Delanzomib, Marizomib, Ixazomib and Velcade, which is another name for Bortezomib, selectively inhibit the threonine protease activity of the proteasome. These actions can lead to the interruption of the normal turnover of proteins regulated by the UPS, thus influencing the functional role of FAM120B in this pathway.

On the other hand, auranofin inhibits the deubiquitinating enzymes of the proteasome. By interfering with deubiquitination, auranofin can prevent the recycling of ubiquitin, which is an essential molecule for marking proteins for degradation. Without the correct functioning of deubiquitinating enzymes, proteins destined to be degraded by the proteasome, which would include those in the functional sphere of FAM120B, can accumulate and disrupt cellular homeostasis.