FADS1 Activators
FADS1 activators belong to a class of compounds known for their role in modulating the activity of the Fatty Acid Desaturase 1 (FADS1) enzyme. FADS1 is a key enzyme in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), such as arachidonic acid (ARA) and eicosapentaenoic acid (EPA), which are essential components of cell membranes and play vital roles in various physiological processes, including inflammation, immune response, and brain development. FADS1 activators are compounds that interact with and enhance the enzymatic activity of FADS1, thereby promoting the conversion of precursor fatty acids into LC-PUFAs.
The activation of FADS1 by these compounds is crucial for the efficient synthesis of LC-PUFAs in the human body. LC-PUFAs, particularly ARA and EPA, serve as precursors for the production of bioactive lipid mediators, such as prostaglandins, leukotrienes, and resolvins, which are involved in the regulation of numerous cellular functions. FADS1 activators play an important role in regulating the balance of these bioactive lipids, influencing various physiological processes, including inflammation resolution, immune cell function, and the maintenance of overall cellular membrane fluidity. Consequently, these compounds are of interest to researchers studying the molecular mechanisms underlying fatty acid metabolism and its implications for human health.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
An omega-6 fatty acid and a substrate for FADS1. Its abundance can stimulate FADS1 activity for conversion to arachidonic acid. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
EPA can modulate the fatty acid composition in membranes, potentially influencing FADS1 expression and activity. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA can alter membrane lipid composition, which might affect FADS1 expression and activity. | ||||||
Palmitoleic acid | 373-49-9 | sc-205424 sc-205424A sc-205424B sc-205424C sc-205424D | 100 mg 500 mg 1 g 5 g 10 g | $32.00 $132.00 $233.00 $1019.00 $1870.00 | 4 | |
A monounsaturated fat potentially produced by FADS1, its presence may signal the need for enhanced FADS1 activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Involved in lipid metabolism and signaling, it can influence FADS1 activity. | ||||||
5α-Cholestane | 481-21-0 | sc-214348 sc-214348A | 100 mg 1 g | $90.00 $230.00 | 1 | |
Inhibits stearoyl-CoA desaturase, potentially upregulating FADS1 activity as a compensatory mechanism. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
A PPARα agonist, GW7647 can modulate lipid metabolism, potentially enhancing FADS1 activity by altering lipid homeostasis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
An AMP-activated protein kinase activator, influencing lipid metabolism and possibly affecting FADS1 activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
A PPARγ agonist known to modulate lipid metabolism, possibly affecting FADS1 activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Another PPARγ agonist, potentially influencing FADS1 activity by modulating lipid metabolism. | ||||||