ephrin-B3 Inhibitors
Ephrin-B3 inhibitors are a class of chemical compounds designed to target and modulate the activity of ephrin-B3, a member of the ephrin family of cell surface proteins. Ephrins are crucial molecules involved in various cellular processes, including cell-cell communication, tissue development, and neural circuit formation. Ephrin-B3, in particular, plays a pivotal role in axon guidance, neuronal migration, and synapse formation within the central nervous system.
The primary mechanism of action of ephrin-B3 inhibitors lies in their ability to disrupt the binding interaction between ephrin-B3 and its cognate receptor, EphB, which belong to the receptor tyrosine kinase family. This interaction is essential for transmitting bidirectional signals that guide axonal growth and regulate cell positioning during neural development. By interfering with this interaction, ephrin-B3 inhibitors have the ability to influence the wiring of neural circuits, making them a valuable tool for researchers studying neurodevelopmental processes, neural plasticity, and neurological disorders. These inhibitors can be instrumental in investigating the intricate molecular mechanisms underlying neural connectivity and may offer insights into the development of novel approaches for addressing neurodevelopmental and neurological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may down-regulate ephrin-B3 expression by modulating transcription factors and signaling pathways such as NF-κB which are known to influence ephrin gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could inhibit ephrin-B3 through its action on the SIRT1 pathway, which is involved in the regulation of gene expression and may affect ephrin-B3. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane has been shown to affect gene expression through epigenetic mechanisms, potentially decreasing ephrin-B3 expression by modifying histone acetylation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can modulate various signaling pathways and may suppress the expression of ephrin-B3 by inhibiting kinase pathways that regulate its expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol in green tea, might reduce ephrin-B3 levels by altering the activity of transcription factors that control its gene expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that can inhibit tyrosine kinases and could down-regulate ephrin-B3 expression by interfering with intracellular signaling. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is known to modulate gene expression and might inhibit ephrin-B3 by influencing the signaling pathways that regulate its transcription. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol, found in cruciferous vegetables, may modulate hormone levels and related pathways, potentially leading to the down-regulation of ephrin-B3 expression. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid could inhibit ephrin-B3 expression through its influence on the NF-κB pathway and other signaling mechanisms that control gene expression. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silybin is known to affect cellular signaling and may down-regulate the expression of ephrin-B3 by inhibiting pathways that promote its expression. | ||||||