Date published: 2026-5-21

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EP4 Activators

EP4 activators represent a distinct chemical category known for their ability to engage and stimulate the EP4 receptor, a subtype within the prostaglandin E2 (PGE2) receptor family. These compounds are designed to selectively target the EP4 receptor while minimizing interactions with other PGE2 receptor subtypes, namely EP1, EP2, and EP3. The EP4 receptor, a member of the G protein-coupled receptor (GPCR) family, is ubiquitously distributed across various cell types within the human body. When EP4 activators interact with this receptor, they initiate a cascade of intracellular signaling events that subsequently influence a wide range of physiological responses. The EP4 receptor is recognized for its involvement in diverse biological processes, spanning immune regulation, inflammatory responses, pain perception, cardiovascular functions, and gastrointestinal homeostasis. EP4 activators serve as indispensable tools in scientific research and pharmacological development, enabling the precise manipulation of EP4 receptor activity. By selectively engaging the EP4 receptor, researchers can dissect its specific roles in these intricate processes. The versatility of EP4 activators within this chemical class allows for precise modulation of experimental conditions, facilitating the exploration of the nuances within PGE2 signaling and its profound impact on various biological systems. This class of compounds plays a pivotal role in unraveling the complexities of EP4 receptor function and its potential implications for future applications.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

11-deoxy Prostaglandin E1

37786-00-8sc-223150
sc-223150A
500 µg
1 mg
$50.00
$71.00
(0)

11-deoxy Prostaglandin E1, as an EP4 agonist, exhibits remarkable specificity in its molecular interactions, particularly through its affinity for the EP4 receptor. This compound engages in unique signaling pathways, modulating intracellular cAMP levels and influencing downstream effects. Its structural conformation allows for selective binding, enhancing its reactivity with G-proteins. The compound's dynamic behavior in biological systems underscores its role in fine-tuning cellular responses.

Misoprostol

59122-46-2sc-201264
sc-201264A
sc-201264B
10 mg
100 mg
1 g
$183.00
$1149.00
$7080.00
2
(1)

Misoprostol, as an EP4 agonist, demonstrates a distinctive ability to modulate cellular signaling through its selective interaction with the EP4 receptor. This compound initiates a cascade of intracellular events, notably influencing calcium mobilization and nitric oxide synthesis. Its unique stereochemistry facilitates specific receptor binding, enhancing its efficacy in activating G-protein coupled pathways. The compound's kinetic profile reveals rapid onset and sustained action, highlighting its intricate role in cellular communication.

TCS 2510

346673-06-1sc-361377
1 mg
$217.00
2
(0)

TCS 2510, functioning as an EP4, exhibits remarkable selectivity in binding to the EP4 receptor, triggering a series of downstream signaling events. Its unique structural features promote specific interactions with lipid membranes, enhancing its bioavailability. The compound's reaction kinetics are characterized by a rapid association and dissociation with the receptor, leading to a pronounced modulation of cyclic AMP levels. This dynamic behavior underscores its potential in influencing various physiological processes.

PGE2

363-24-6sc-201225
sc-201225C
sc-201225A
sc-201225B
1 mg
5 mg
10 mg
50 mg
$57.00
$159.00
$275.00
$678.00
37
(1)

PGE2 itself is a natural ligand for EP4 receptors and plays a crucial role in regulating various physiological processes.

Butaprost

69685-22-9sc-221387
sc-221387A
500 µg
1 mg
$126.00
$242.00
1
(0)

Butaprost is a synthetic EP4 agonist commonly used in research to study the functions of EP4 receptors.

2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid

64054-40-6sc-223250
sc-223250A
500 µg
1 mg
$116.00
$220.00
(0)

CAY10580 is another synthetic EP4 receptor agonist used in scientific studies to activate EP4 receptors.

5′,6′-Epoxyeicosatrienoic acid

87173-80-6sc-221066A
sc-221066
sc-221066B
sc-221066C
25 µg
50 µg
100 µg
500 µg
$56.00
$102.00
$179.00
$562.00
4
(0)

This natural epoxyeicosatrienoic acid is known to activate EP4 receptors and is involved in regulating vascular tone.

Sulprostone

60325-46-4sc-201348
sc-201348A
1 mg
5 mg
$224.00
$774.00
8
(1)

Sulprostone is a synthetic prostaglandin E2 analog that can activate EP4 receptors and is used in medical applications such as inducing labor.