EG546368 Inhibitors
Cldn34c5, also known as Gm5945, stands as a gene with broad expression, particularly in the testis in adults and the whole brain at E14.5. The recent data indicates its intriguing localization within the mitochondrion, a distinctive feature among claudin family members. While the precise function of Cldn34c5 in this organelle remains under investigation, potential mechanisms of inhibition can be postulated based on mitochondrial processes.
Mitochondrial division inhibitors, electron transport chain disruptors, and mitochondrial reactive oxygen species scavengers represent potential avenues for direct or indirect inhibition. These compounds target critical mitochondrial processes, such as dynamics, energy production, and redox balance, which could impact the subcellular localization and function of Cldn34c5 within the mitochondrion. Understanding the interplay between mitochondrial dynamics and Cldn34c5's function offers a glimpse into the intricate regulatory mechanisms governing this unique claudin's role in cellular physiology. As research on Cldn34c5 progresses, elucidating its precise functions within the mitochondrion will be essential for refining potential inhibition strategies and unraveling its contributions to cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
A well-known inhibitor of mitochondrial division, Mdivi-1 interferes with the process of mitochondrial fission by targeting Drp1. This compound could potentially impact the dynamic processes associated with Cldn34c5 within the mitochondrion, influencing its function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is a natural compound that disrupts the electron transport chain (ETC) in mitochondria by inhibiting complex I. This disruption can indirectly affect Cldn34c5 by altering the mitochondrial environment and the associated regulatory mechanisms. | ||||||
Mito-TEMPO | 1569257-94-8 | sc-221945 sc-221945A | 5 mg 25 mg | $66.00 $255.00 | 136 | |
MitoTEMPO is a mitochondria-targeted antioxidant that scavenges reactive oxygen species (ROS) within the mitochondrion. This indirect inhibitor may influence the redox balance and regulatory pathways associated with Cldn34c5 in the mitochondrial context. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
Carbonyl cyanide m-chlorophenyl hydrazone (CCCP) disrupts mitochondrial membrane potential, impacting the structural integrity of the mitochondrial membrane. This could potentially affect the subcellular localization and function of Cldn34c5 within the mitochondrion. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
Ethidium bromide inhibits mitochondrial DNA replication by intercalating with DNA. This indirect inhibitor may impact the regulatory mechanisms of Cldn34c5, potentially influencing its function within the mitochondrion. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium red modulates mitochondrial calcium ion levels. This indirect inhibitor may influence the calcium-dependent regulatory pathways associated with Cldn34c5 within the mitochondrion, potentially impacting its function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin inhibits mitochondrial ATP synthase, disrupting oxidative phosphorylation. This indirect inhibitor may impact the mitochondrial environment, altering the subcellular localization and function of Cldn34c5 within the mitochondrion. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, affecting protein degradation pathways. This potential direct inhibitor may impact the degradation of mitochondrial proteins, influencing the subcellular localization and function of Cldn34c5 within the mitochondrion. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), influencing mitochondrial biogenesis. This indirect inhibitor may impact the regulatory mechanisms associated with Cldn34c5, potentially influencing its function within the mitochondrion. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) disrupts the integrity of the mitochondrial inner membrane, potentially influencing the subcellular localization and function of Cldn34c5 within the mitochondrion. | ||||||