EG236663 Inhibitors
H2al1j, predicted to enable DNA binding activity and play a role in heterochromatin assembly, emerges as a crucial player in chromatin dynamics and genomic organization. The direct and indirect inhibitors presented in the table showcase the intricate ways by which H2al1j could be modulated. Direct inhibitors like A-485 and C646 target specific aspects of chromatin modification, affecting the DNA binding activity of H2al1j. Meanwhile, indirect inhibitors such as GSK-J4 and Nutlin-3 influence pathways that, in turn, impact H2al1j, demonstrating the complexity of its regulatory network.
Inhibition of H2al1j involves interference at multiple levels, including histone modification, DNA topology, and DNA repair. Compounds like Etoposide and BML-210 indirectly affect H2al1j by inducing DNA damage or impairing DNA repair mechanisms. Others, such as BIX-01294 and UNC1999, modulate histone methylation patterns, potentially disrupting chromatin structure and impacting H2al1j's role in heterochromatin assembly. This comprehensive approach to inhibition underscores the versatile functions of H2al1j in chromatin biology and provides a foundation for further investigations into its specific contributions to cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
Histone deacetylase (HDAC) inhibitor affecting chromatin structure. Modifies the acetylation status of histones, potentially disrupting the binding of H2al1j to DNA and hindering its DNA binding activity, leading to inhibition. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor. Alters DNA methylation patterns, potentially influencing heterochromatin assembly and inhibiting the role of H2al1j in this process. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Topoisomerase II inhibitor affecting DNA topology. Indirectly influences H2al1j by inducing DNA damage, potentially disrupting its DNA binding activity and interfering with its role in DNA-related processes. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
G9a histone methyltransferase inhibitor. Modifies histone methylation patterns, potentially influencing chromatin structure and indirectly inhibiting H2al1j's involvement in heterochromatin assembly. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2 inhibitor affecting p53 pathway. Indirectly influences H2al1j by altering the p53-mediated response, potentially impacting its DNA binding activity and involvement in cellular processes. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
Histone acetyltransferase (HAT) inhibitor. Modifies histone acetylation patterns, potentially influencing chromatin structure and disrupting H2al1j's DNA binding activity, leading to inhibition. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
EZH2 histone methyltransferase inhibitor. Modulates histone methylation, potentially impacting chromatin structure and interfering with H2al1j's involvement in heterochromatin assembly. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Cyclin-dependent kinase (CDK) inhibitor. Modulates cell cycle progression, indirectly influencing H2al1j by altering the cell cycle dynamics, potentially impacting its DNA binding activity and cellular functions. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Tankyrase inhibitor affecting Wnt/β-catenin pathway. Indirectly influences H2al1j by modulating the Wnt pathway, potentially impacting its DNA binding activity and cellular processes related to heterochromatin assembly. | ||||||