The chemical class termed EF-CAB7 Activators refers to a specific group of compounds recognized for their capacity to modulate the activity of the EF-CAB7 gene. EF-CAB7, or Elongation Factor-Cation Channel Complex Subunit B7, is a gene encoding a protein that plays a crucial role in the elongation phase of protein synthesis. This gene product is involved in forming a complex with the elongation factor EF-1 alpha and a calcium channel, facilitating the entry of calcium ions into the cell during protein synthesis. While the precise function of EF-CAB7 is not fully elucidated, it is believed to contribute to the regulation of protein synthesis and possibly participate in calcium signaling pathways within the cell. Activators of EF-CAB7 are substances capable of enhancing the expression or function of this gene, potentially influencing downstream cellular pathways and biological responses associated with its activity.
Characterizing compounds as EF-CAB7 Activators typically involves comprehensive screening processes aimed at evaluating their ability to interact with regulatory elements of the EF-CAB7 gene or modulate the activity of proteins associated with its expression or function. These activators may operate through various mechanisms, such as binding to specific DNA sequences within the gene promoter region, regulating the activity of transcription factors responsible for EF-CAB7 gene expression, or modulating post-translational modifications of the EF-CAB7 protein. Understanding the molecular mechanisms underlying EF-CAB7 activation by these compounds is crucial for elucidating the roles of EF-CAB7 in cellular physiology and protein synthesis. Further research into EF-CAB7 Activators may provide insights into novel cellular pathways and contribute to a deeper understanding of EF-CAB7's function in cellular homeostasis and protein synthesis regulation.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, leading to increased cAMP levels, which could influence calcium signaling and gene expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
An ionophore that increases intracellular calcium levels, potentially affecting EF-hand domain-containing protein expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Inhibits the ER Ca²⁺-ATPase, increasing cytosolic calcium and possibly inducing gene expression changes. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
L-type calcium channel blocker that can alter intracellular calcium dynamics and potentially gene expression. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Another calcium channel blocker that may indirectly influence expression of calcium-responsive genes. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Inhibits ryanodine receptors on the sarcoplasmic reticulum, possibly affecting calcium-mediated gene expression. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A cell-permeable calcium chelator that can modulate calcium signaling, potentially impacting gene expression. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
Mimics diacylglycerol, activating protein kinase C and potentially influencing calcium-related gene expression. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Acts as a calcium channel agonist potentially affecting calcium influx and gene expression. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
A blocker of receptor-mediated calcium entry channels, possibly altering gene expression. |