Date published: 2026-5-24

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EEA1 Inhibitors

EEA1 (Early Endosome Antigen 1) is a crucial protein involved in the endocytic pathway, a cellular process responsible for the internalization and sorting of membrane components, soluble molecules, and extracellular substances. EEA1 plays a significant role in the tethering and fusion of early endosomes, which are vesicular structures formed immediately after endocytosis. This protein contains a FYVE domain, a zinc-finger motif that allows it to specifically bind to phosphatidylinositol 3-phosphate (PI3P) present on early endosomal membranes. Through this interaction, EEA1 helps ensure the proper docking and subsequent fusion of endosomal membranes, facilitating the efficient transport, processing, and recycling or degradation of endocytosed material. EEA1 inhibitors are molecules designed to interfere with the function of EEA1, thereby affecting the endocytic pathway at the early endosome stage. By targeting and disrupting the activity of EEA1, these inhibitors can hinder early endosome fusion, leading to perturbations in the normal trafficking and processing of internalized substances within the cell. This interference can be achieved through various mechanisms. Some inhibitors might block the binding of EEA1 to PI3P on the endosomal membrane, while others could interfere with the protein's ability to mediate membrane tethering and fusion.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a PI3K inhibitor, which might interrupt PI3P synthesis, a lipid binding partner of EEA1. This could potentially lead to reduced EEA1 expression or function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is another PI3K inhibitor. By inhibiting PI3K, it might interfere with EEA1's function in endosomal tethering, which could impact its expression.

Autophagy Inhibitor, 3-MA

5142-23-4sc-205596
sc-205596A
50 mg
500 mg
$65.00
$261.00
113
(3)

3-MA is an inhibitor of PI3K. By blocking PI3K activity, 3-MA might reduce EEA1's role in endosomal tethering and possibly its expression.

Dynamin Inhibitor I, Dynasore

304448-55-3sc-202592
10 mg
$89.00
44
(2)

Dynasore inhibits dynamin, which is involved in endocytosis. This could indirectly affect EEA1's function and expression in early endosome tethering.

Pitstop 2

1419320-73-2sc-507418
10 mg
$360.00
(0)

Pitstop 2 inhibits clathrin-mediated endocytosis, potentially impacting the endosomal pathway and EEA1's expression or function.

Spautin-1

1262888-28-7sc-507306
10 mg
$168.00
(0)

Spautin-1 promotes the degradation of VPS34 complexes, possibly affecting PI3P levels and, in turn, EEA1's function and expression.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$61.00
$110.00
21
(1)

Chlorpromazine affects clathrin-mediated endocytosis, which could impact EEA1's role in endosomal trafficking and potentially its expression.

Hydroxy-Dynasore

1256493-34-1sc-364678
10 mg
$255.00
(0)

As a dynamin inhibitor, Hydroxy-Dynasore might affect endocytosis and thus potentially impact EEA1's function or expression.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$98.00
$255.00
$765.00
$1457.00
280
(6)

Bafilomycin A1 inhibits vacuolar H+ ATPases, affecting endosomal acidification. This could indirectly impact EEA1's function and expression.

Concanamycin A

80890-47-7sc-202111
sc-202111A
sc-202111B
sc-202111C
50 µg
200 µg
1 mg
5 mg
$66.00
$167.00
$673.00
$2601.00
109
(2)

Similar to Bafilomycin A1, Concanamycin A inhibits vacuolar H+ ATPases, which might indirectly affect EEA1's role in endosomal tethering and its expression.