EDG-8 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SEW2871 | 256414-75-2 | sc-203251 sc-203251A | 5 mg 10 mg | $38.00 $53.00 | 1 | |
SEW2871 inhibits EDG-8 by specifically targeting the receptor and blocking its activation by sphingosine-1-phosphate (S1P). This inhibition disrupts the S1P signaling pathway, leading to downstream effects on cellular processes regulated by EDG-8, such as cell migration, proliferation, and survival. | ||||||
PF-543 | 1415562-82-1 | sc-507507 | 10 mg | $210.00 | ||
PF-543 inhibits EDG-8 by targeting sphingosine kinase (SphK), the enzyme responsible for generating S1P. By blocking SphK, PF-543 disrupts the synthesis of S1P, preventing its interaction with EDG-8 and thereby inhibiting downstream signaling events associated with EDG-8 activation. | ||||||
2-undecyl-thiazolidine-4-carboxylic acid | 298186-80-8 | sc-220768 sc-220768A | 5 mg 10 mg | $88.00 $166.00 | ||
Also called BML-241, this compound inhibits EDG-8 by acting as a selective antagonist, preventing the binding of S1P to the receptor. This antagonistic action disrupts the normal activation of EDG-8 by S1P, leading to alterations in the signaling cascades controlled by EDG-8 and influencing cellular responses such as migration, proliferation, and survival. | ||||||
VPC 23019 | 449173-19-7 | sc-362817 | 10 mg | $364.00 | 4 | |
VPC-23019 inhibits EDG-8 by specifically targeting the receptor and interfering with its coupling to G proteins. This disruption of the G protein-mediated signaling pathway prevents the downstream effects of EDG-8 activation, impacting cellular processes regulated by EDG-8, including cell migration, proliferation, and survival. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 inhibits EDG-8 by acting as a functional antagonist, causing internalization and degradation of the receptor. This internalization prevents the activation of EDG-8 by S1P and disrupts downstream signaling events, influencing cellular processes like cell migration, proliferation, and survival regulated by EDG-8. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine inhibits EDG-8 by competitively binding to the receptor, preventing the activation of EDG-8 by S1P. This competitive inhibition disrupts the normal signaling cascade initiated by EDG-8 activation, leading to alterations in cellular processes such as cell migration, proliferation, and survival regulated by EDG-8. | ||||||
W146 | 909725-61-7 | sc-507557 | 1 mg | $525.00 | ||
W146 inhibits EDG-8 by acting as a selective antagonist, preventing the binding of S1P to the receptor. This antagonistic action disrupts the normal activation of EDG-8 by S1P, leading to alterations in the signaling cascades controlled by EDG-8 and influencing cellular responses such as migration, proliferation, and survival. | ||||||
JTE 013 | 383150-41-2 | sc-203615 | 10 mg | $195.00 | 5 | |
JTE-013 inhibits EDG-8 by specifically targeting the receptor and blocking its activation by S1P. This inhibition disrupts the S1P signaling pathway, leading to downstream effects on cellular processes regulated by EDG-8, such as cell migration, proliferation, and survival. | ||||||