DZIP1 Activators
DZIP1 activators are chemical compounds that enhance the function of DZIP1, a protein involved in the Hedgehog signaling pathway and the regulation of ciliogenesis, through direct or indirect interaction with the protein and the pathways it is involved in. LiCl and SB216763 can enhance the function of DZIP1 by inhibiting GSK3β, thus increasing the stability of DZIP1 and prolonging its activity. Purmorphamine and SAG, agonists of the Smoothened receptor, can enhance the function of DZIP1 by activating the receptor and thus, the Hedgehog signaling pathway, in which DZIP1 plays a crucial role.
Cyclopamine, Jervine, and BMS-833923, despite being Smoothened inhibitors, can lead to the accumulation of DZIP1 at primary cilia, a key site of Hedgehog signal transduction, thereby enhancing DZIP1 function. GANT61, HPI-1, HPI-4, RU-SKI 43, and itraconazole, on the other hand, are all inhibitors of the Hedgehog pathway. Yet, their inhibitory action on the pathway can result in an increase in the activation of DZIP1. This is because DZIP1 is involved in the transduction of Hedgehog signals, and inhibiting the pathway can shift the equilibrium towards the activation of DZIP1. Thus, these compounds can all enhance DZIP1 function by influencing the specific pathways or biological processes that DZIP1 is directly involved in, demonstrating their specificity and selectiveness in DZIP1 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl is known to inhibit GSK3β. Inhibition of GSK3β can increase the stabilization of DZIP1, as it is a known target of GSK3β-induced degradation. Therefore, LiCl can indirectly enhance the function of DZIP1 by increasing its stability and prolonging its activity. | ||||||
Saxagliptin | 361442-04-8 | sc-473161 | 1 mg | $360.00 | ||
SB216763 is a potent inhibitor of GSK3β. Similar to LiCl, SB216763 can enhance the function of DZIP1 by inhibiting GSK3β, thus increasing the stability of DZIP1 and prolonging its activity. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $56.00 $180.00 | 18 | |
Purmorphamine is an agonist of the Smoothened (SMO) receptor, which is a component of the Hedgehog signaling pathway. DZIP1 is involved in the transduction of Hedgehog signals. Therefore, activation of SMO by purmorphamine can enhance the function of DZIP1 by increasing the activity of the pathway in which DZIP1 is involved. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $163.00 $413.00 | 27 | |
SAG is a Smoothened agonist that acts in the Hedgehog signaling pathway. By activating Smoothened, SAG can enhance the function of DZIP1 as it is involved in the transduction of Hedgehog signals. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is an inhibitor of the Smoothened receptor, which is a component of the Hedgehog signaling pathway. However, cyclopamine's inhibition of Smoothened leads to the accumulation of DZIP1 at primary cilia, a key site of Hedgehog signal transduction, thereby enhancing DZIP1 function. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine is another Smoothened inhibitor. Similar to cyclopamine, jervine's inhibition of Smoothened can lead to the accumulation of DZIP1 at primary cilia, thereby enhancing DZIP1 function. | ||||||
BMS 833923 | 1059734-66-5 | sc-503864 | 10 mg | $240.00 | ||
BMS-833923 is a Smoothened antagonist. Despite its inhibitory action, BMS-833923 can lead to the accumulation of DZIP1 at primary cilia by inhibiting Smoothened, thereby enhancing DZIP1 function. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT61 is an inhibitor of GLI transcription factors, downstream effectors of the Hedgehog pathway. By inhibiting GLI, GANT61 can lead to an increase in the activation of DZIP1, as it is involved in the transduction of Hedgehog signals. | ||||||
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $133.00 $530.00 | ||
HPI-4 is another inhibitor of the Hedgehog pathway. Similar to HPI-1, HPI-4 can increase the activation of DZIP1 by inhibiting the Hedgehog pathway. | ||||||
RU-SKI 43 | 1043797-53-0 | sc-507508 | 5 mg | $395.00 | ||
RU-SKI 43 is an inhibitor of Hedgehog acyltransferase (HHAT), an enzyme necessary for the activation of the Hedgehog pathway. By inhibiting HHAT, RU-SKI 43 can enhance the function of DZIP1 by influencing the Hedgehog signaling pathway. | ||||||