Date published: 2026-5-15

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Dynamin Inhibitors

Dynamin is a pivotal GTPase protein that plays a central role in membrane remodeling, vesicle formation, and cellular trafficking processes. Its primary function revolves around the scission of vesicles from cellular membranes during endocytosis, enabling the internalization of various molecules and receptors. Dynamin is also implicated in processes like synaptic vesicle recycling and mitochondrial fission. Through its GTPase activity, dynamin assembles into helical structures around membrane necks, ultimately inducing membrane constriction and vesicle detachment. This dynamic process is regulated by various factors, including GTP binding and hydrolysis. Dysregulation of dynamin activity can lead to disruptions in endocytosis and other cellular functions. Dynamin inhibitors hold significant implications in understanding cellular processes dependent on membrane dynamics and vesicle trafficking. These inhibitors offer researchers a means to dissect the precise contributions of dynamin in various contexts, such as endocytosis, synaptic transmission, and mitochondrial dynamics. By blocking dynamin's GTPase activity or its interactions with associated proteins, these inhibitors allow researchers to observe the consequences of impaired vesicle formation and endocytic pathways.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Hydroxy-Dynasore

1256493-34-1sc-364678
10 mg
$255.00
(0)

Dyngo-4a functions as a specific dynamin inhibitor, targeting the GTPase activity of dynamin. Its application has been extensive in inhibiting clathrin-mediated endocytosis by disrupting the formation of clathrin-coated vesicles. Dyngo-4a proves to be a valuable tool in probing the intricacies of dynamin's role in endocytic processes.

Dynamin Inhibitor I, Dynasore

304448-55-3sc-202592
10 mg
$89.00
44
(2)

Extensively studied, Dynasore is a small molecule inhibitor that effectively hinders dynamin's GTPase activity. By curtailing dynamin, Dynasore disrupts both endocytosis and vesicle formation. Its application has been widespread in cellular studies investigating dynamin's involvement in diverse processes.

Pindolol

13523-86-9sc-204847
sc-204847A
100 mg
1 g
$194.00
$760.00
(1)

Initially a beta-blocker employed to Hypertension, pindolol was serendipitously identified as an inhibitor of dynamin, resulting in the inhibition of endocytosis. This unexpected attribute prompted its recognition as a possible dynamin inhibitor, underpinning its role in cellular investigations.

Mdivi-1

338967-87-6sc-215291
sc-215291B
sc-215291A
sc-215291C
5 mg
10 mg
25 mg
50 mg
$67.00
$126.00
$251.00
$465.00
13
(2)

Mdivi-1, a compound with selective action, hampers mitochondrial fission, encompassing the activity of dynamin-related protein DRPIts application has extended to the exploration of mitochondrial dynamics and possible therapeutic applications.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$55.00
$131.00
$203.00
$317.00
23
(1)

Though not designed as a dedicated dynamin inhibitor, calcimycin influences dynamin-dependent endocytosis by interfering with intracellular calcium levels. Its effects on calcium-regulated pathways lead to indirect impacts on dynamin.

Urolithin A

1143-70-0sc-475514
sc-475514A
sc-475514B
sc-475514C
25 mg
100 mg
1 g
5 g
$204.00
$459.00
$714.00
$1224.00
10
(0)

Urolithin A, a naturally occurring compound, has shown its ability to influence mitochondrial dynamics by affecting the function of dynamin-related protein DRPIts impact extends to cellular homeostasis and mitochondrial health.