DUX4 Activators
DUX4 activators refer to a group of chemical entities that modulate the activity of the DUX4 protein, a transcription factor encoded by the DUX4 gene. This gene is of particular interest due to its involvement in the regulation of gene expression during early embryonic development. DUX4 is known for its role in activating genes associated with cellular pathways related to development, differentiation, and possibly muscle atrophy when aberrantly expressed.
Direct activators of DUX4 would likely interact with the protein at specific domains, altering its conformation to enhance its ability to bind to DNA and recruit the transcriptional machinery, thus promoting the expression of target genes. These compounds could bind to the DUX4 protein and induce a structural change that increases its stability or prevents its degradation, leading to an increase in DUX4 activity within the nucleus. Indirect DUX4 activators could function by upregulating the DUX4 gene expression, leading to an increased production of the DUX4 protein. They might also act by modulating signaling pathways that influence the transcription or translation of DUX4, or by inhibiting the ubiquitin-proteasome system that targets DUX4 for degradation, thus prolonging the protein's half-life in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can induce ER stress. The ER stress response upregulates ATF4, a transcription factor known to bind and activate DUX4. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that causes ER stress, leading to ATF4 upregulation. ATF4 can bind to and activate DUX4. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin causes ER stress by inhibiting N-linked glycosylation. This leads to ATF4 upregulation, which can activate DUX4. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis, which can induce ER stress and subsequently upregulates ATF4. ATF4 is known to bind and activate DUX4. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA, causing DNA damage and leading to p53 upregulation. p53 has been shown to indirectly activate DUX4. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II leading to DNA breakage and p53 upregulation. p53 can indirectly activate DUX4. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil incorporates into DNA and RNA, leading to DNA damage and p53 upregulation. The upregulation of p53 can indirectly activate DUX4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is an activator of SIRT1, a known deacetylase of p53. Activated p53 can indirectly modulate DUX4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is an activator of p300, a known acetylase of p53. Activated p53 can indirectly modulate DUX4. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can increase histone acetylation, leading to an open chromatin conformation for DUX4 activation. | ||||||