DREAM Activators

DREAM activators, as listed here, are primarily chemicals that influence calcium signaling or neuronal activity, which can indirectly affect DREAM's function. These compounds do not directly interact with DREAM but modulate the cellular environment and pathways critical to DREAM's roles. Calcium channel blockers such as Nimodipine, Isradipine, Nifedipine, Amlodipine, and Verapamil influence intracellular calcium levels, which are crucial for the activation and function of DREAM. DREAM is known to be calcium-sensitive, and changes in calcium dynamics could therefore modulate its activity.

Agents like Dantrolene and Ryanodine, which affect calcium release from the sarcoplasmic reticulum, and Thapsigargin, an ER calcium pump inhibitor, also play a role in modulating calcium homeostasis, potentially impacting DREAM activity. Caffeine and BAPTA-AM represent different mechanisms of influencing calcium signaling, with caffeine affecting calcium release channels and BAPTA-AM being a calcium chelator. These compounds might indirectly alter DREAM function through changes in calcium signaling. Neuroactive substances like Tetrodotoxin, which blocks sodium channels, and Gabapentin, which affects calcium channels, could influence neuronal activity and indirectly modulate DREAM function, given DREAM's involvement in neuronal processes.