DPF1 Activators

Histone deacetylase inhibitors like Trichostatin A, SAHA, Valproic Acid, Mocetinostat, Entinostat, and Panobinostat could modulate the chromatin landscape, enhancing DPF1's ability to regulate gene expression. By altering histone acetylation levels, these compounds might indirectly affect DPF1's interaction with chromatin, thereby influencing its role in transcriptional regulation and possibly neuronal development.

DNA methyltransferase inhibitors such as 5-Azacytidine and RG108, along with histone methyltransferase inhibitors like BIX-01294, EPZ-6438, UNC1999, and the BET bromodomain inhibitor JQ1, target different aspects of the epigenetic machinery. These compounds can alter DNA methylation and histone modification patterns, impacting DPF1's function in epigenetic regulation of gene expression. The alteration of the epigenetic landscape could influence the transcriptional control exerted by DPF1, particularly in processes like development and differentiation where epigenetic regulation is crucial.