DHRS13 Activators

Retinoic acid finely tunes cellular differentiation and proliferation by binding to nuclear receptors, which could enhance the expression and activity of DHRS13. Peroxisome proliferators activate PPARs, leading to transcriptional changes that may encompass the upregulation of dehydrogenase/reductase enzymes, thus potentially increasing DHRS13 activity. Compounds like insulin set off a cascade of signaling pathways that shape metabolic processes, altering the expression or activity of metabolic enzymes, including DHRS13. Forskolin, through its ability to raise cAMP levels, exerts a broad influence on cellular signaling, which may promote the transcription and subsequent activity of DHRS13. Phorbol esters, by engaging protein kinase C, can trigger a signaling domino effect, modifying pathways that affect DHRS13's function and expression.

Epigallocatechin gallate (EGCG) and curcumin, through their interactions with multiple signaling pathways, might modulate transcription factors or signaling molecules, thereby altering DHRS13's activity. Resveratrol, by impacting sirtuin activity, and sulforaphane, through the activation of Nrf2, both have the capacity to influence the expression of a range of metabolic enzymes, which could include DHRS13. Further, pioglitazone, as a PPARγ agonist, and 1,1-Dimethylbiguanide, Hydrochloride, by activating AMP-activated protein kinase, can both instigate genetic and enzymatic shifts that might affect DHRS13. Niacin serves as a precursor for NAD+/NADP+, essential co-factors for dehydrogenase/reductase enzymes like DHRS13, potentially affecting its enzymatic activity.