DDX24 Activators
DDX24 activators are chemical agents designed to enhance the activity of the DEAD-box protein 24 (DDX24), which is an ATP-dependent RNA helicase. DDX24 is a member of the DEAD-box protein family, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), and is involved in various aspects of RNA metabolism, including RNA splicing, ribosome assembly, and the initiation of translation. The activity of DDX24, as with other RNA helicases, is critical for unwinding RNA structures and remodeling ribonucleoprotein complexes, which is essential for the proper functioning of cellular RNA-dependent processes. Activators of DDX24 are designed to promote these activities, thereby influencing the dynamics of RNA metabolism.
The development of DDX24 activators involves the identification of small molecules that can bind to the protein and increase its helicase activity. This may involve the stabilization of the protein in a conformation that is more active or enhancing its interaction with ATP, which is necessary for the helicase activity. The exact mechanism by which these activators function can vary, but they often target the ATPase or RNA-binding domains of DDX24 to exert their effects. The design of such molecules requires a detailed understanding of the protein's structure and the conformational changes that it undergoes during the RNA unwinding process. Structural studies, such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy, provide a three-dimensional view of the protein, which is instrumental in the rational design of activators that can interact with DDX24 in a precise manner. Additionally, high-throughput screening of compound libraries can identify candidate molecules that increase DDX24 activity, which can then be further optimized through medicinal chemistry approaches.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in red wine, could potentially upregulate DDX24 expression through the activation of SIRT1, a longevity-associated gene known to modulate various cellular processes. This could lead to alterations in the cellular response to environmental stressors, impacting DDX24 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, may enhance DDX24 expression by regulating NF-κB and STAT3 signaling pathways, which are key in cellular responses to stress and inflammation. Through these pathways, curcumin could influence the regulation of proteins like DDX24 that are involved in RNA processing. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone found in soybeans, could potentially increase DDX24 expression by inhibiting protein tyrosine kinases, leading to changes in multiple signaling pathways. These alterations could result in an upregulation of proteins involved in RNA processing like DDX24. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in various fruits and vegetables, may induce DDX24 expression by modulating antioxidant defenses or through its effects on various signaling pathways. Its broad spectrum of activity could potentially influence RNA helicases like DDX24. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic Acid, a common dietary phenol, may stimulate DDX24 expression through the activation of Nrf2, a key regulator of cellular response to oxidative stress. Through this pathway, caffeic acid could influence the expression of proteins like DDX24 that play a role in RNA processing. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, found in cruciferous vegetables, could potentially increase DDX24 expression by activating Nrf2 signaling, which is involved in cellular defense mechanisms. By regulating this pathway, sulforaphane may influence the levels of RNA processing proteins like DDX24. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a catechin from green tea, may enhance DDX24 expression by modulating pathways associated with cellular stress and inflammation. This could lead to changes in the expression of proteins like DDX24 that are involved in RNA processing. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the active component of chili peppers, could potentially increase DDX24 expression through its effect on intracellular calcium levels and related signaling pathways. Its influence on these pathways could lead to an upregulation of RNA helicases like DDX24. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine, a plant alkaloid, might enhance DDX24 expression by inhibiting the mTOR pathway, which is involved in cellular growth and stress responses. This could ultimately impact the levels of proteins involved in RNA processing, such as DDX24. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid, a polyphenol found in various fruits and nuts, could upregulate DDX24 expression through the modulation of NF-κB and MAPK signaling. These pathways are pivotal in cellular stress response, potentially influencing RNA helicases like DDX24. | ||||||