DDX12 Inhibitors
DDX12 Inhibitors belong to a unique category of chemical entities specifically designed to target and inhibit the action of DDX12 protein. DDX12, otherwise known as DEAD-box helicase 12, is a member of the DEAD-box family of RNA helicases. These helicases play a crucial role in various aspects of RNA metabolism, including ribosome biogenesis, RNA splicing, RNA transport, RNA decay, and translation initiation. The DEAD-box helicases derive their name from the conserved Asp-Glu-Ala-Asp (DEAD) motif found in their protein sequences. This motif, along with other conserved motifs, aids these helicases in binding and unwinding RNA in an ATP-dependent manner.
DDX12 inhibitors, as the name suggests, specifically interfere with the functioning of the DDX12 protein, thereby modulating its role in RNA metabolism. The specific mechanism of action of these inhibitors often involves disrupting the ATP binding site, impairing the protein's ATPase activity, or obstructing the RNA binding region of DDX12. By doing so, these compounds can significantly alter cellular processes where DDX12 plays a pivotal role. Given the widespread involvement of RNA helicases in cellular processes, understanding and modulating their action through inhibitors like those targeting DDX12 can offer valuable insights into fundamental biological processes and molecular dynamics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid with antioxidant properties, quercetin might inhibit DDX12 by binding to its ATP-binding pocket, inhibiting its unwinding activity. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Known to interact with RNA and proteins, ellagic acid might affect the RNA-binding or ATP-binding sites of DDX12, impeding its helicase activity. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
While its primary target isn't RNA helicases, there might be downstream effects where DDX12 is indirectly impacted, or there could be off-target effects directly on DDX12. | ||||||
CCG 203971 | 1443437-74-8 | sc-507360 | 10 mg | $89.00 | ||
If it interacts with DDX12, it likely targets the ATP-binding site, preventing the hydrolysis of ATP essential for helicase activity. | ||||||
TBB | 17374-26-4 | sc-202830 sc-202830A sc-202830C sc-202830B sc-202830D | 10 mg 25 mg 50 mg 100 mg 250 mg | $240.00 $363.00 $445.00 $760.00 $1781.00 | 17 | |
This molecule might inhibit DDX12 by binding to the ATP-binding pocket, thus preventing the energy-driven unwinding of RNA. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
While mainly an antimetabolite, its potential impact on DDX12 could be through its incorporation into RNA, making it a poor substrate for unwinding, or through other indirect cellular mechanisms. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
Primarily targets reverse transcriptases. If it inhibits DDX12, it might do so by being incorporated into RNA substrates or by competing for ATP-binding sites. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
This compound's polyanionic nature might allow it to interfere with the RNA or ATP binding sites of DDX12, hindering its helicase activity. | ||||||