DCAR Activators
dcaR, an IclR family transcriptional regulator, plays a pivotal role in bacterial responses to diverse environmental stimuli, particularly those involving aromatic compounds. The gene is involved in coordinating the transcriptional regulation of pathways related to benzoate, chlorobenzoate, and other aromatic compounds. Activation of dcaR is achieved through direct and indirect interactions with a variety of chemicals. These activators, such as triclosan, sodium benzoate, and 2,4-dichlorophenoxyacetic acid (2,4-D), modulate dcaR's regulatory functions by influencing its DNA-binding capacity or upregulating its expression.
Direct activators like 4-nitrophenol and benzoic acid directly engage with dcaR, enhancing its ability to bind to target promoters and modulate gene expression. Indirect activators, including dicamba and diethyl phthalate, influence dcaR through pathways related to auxin signaling and responses to phthalate esters, respectively. These chemicals amplify dcaR's role in coordinating bacterial responses to specific environmental cues. The intricate network of dcaR activation highlights its importance in fine-tuning transcriptional responses to aromatic compounds, showcasing its significance in microbial adaptation to diverse environmental challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan, an antibacterial agent, stimulates dcaR by disrupting bacterial fatty acid synthesis. This leads to the upregulation of dcaR, promoting its transcriptional regulatory functions in bacterial metabolism. | ||||||
Sodium benzoate | 532-32-1 | sc-251009 | 250 g | $21.00 | ||
Sodium benzoate activates dcaR indirectly by influencing the bacterial benzoate degradation pathway. It enhances the expression of dcaR, thereby amplifying its transcriptional regulatory role in coordinating cellular responses to benzoate exposure. | ||||||
2,4-Dichlorophenoxy Acetic Acid | 94-75-7 | sc-205097 sc-205097A sc-205097B sc-205097C sc-205097D | 10 g 25 g 100 g 250 g 500 g | $26.00 $37.00 $48.00 $94.00 $317.00 | 1 | |
2,4-D stimulates dcaR by modulating the bacterial response to herbicides. This indirect activation involves the upregulation of dcaR expression, allowing it to regulate genes involved in the detoxification of herbicidal compounds. | ||||||
Benzoic acid | 65-85-0 | sc-203317 sc-203317A sc-203317B | 25 g 100 g 500 g | $20.00 $51.00 $61.00 | ||
Benzoic acid serves as a direct activator of dcaR by binding to its regulatory site. This interaction enhances dcaR's DNA-binding capacity, promoting the activation of target genes involved in bacterial responses to benzoate and related compounds. | ||||||
3-Chlorobenzoic acid | 535-80-8 | sc-238521 | 25 g | $23.00 | ||
3-Chlorobenzoic acid directly activates dcaR by serving as a substrate for the regulatory protein. This interaction enhances dcaR's ability to bind to target promoters, resulting in the upregulation of genes involved in chlorobenzoate metabolism. | ||||||
Naphthalene | 91-20-3 | sc-215533 sc-215533A | 250 mg 5 g | $20.00 $37.00 | ||
Naphthalene serves as a direct activator of dcaR by inducing its expression in response to aromatic hydrocarbons. This upregulation enables dcaR to play a crucial role in regulating the transcriptional response to naphthalene and related compounds. | ||||||
2,4,5-Trichlorophenol | 95-95-4 | sc-238355 | 25 g | $34.00 | ||
2,4,5-Trichlorophenol stimulates dcaR directly by binding to its regulatory region. This interaction enhances dcaR's DNA-binding activity, leading to the upregulation of target genes involved in bacterial responses to chlorinated phenolic compounds. | ||||||
Diethyl phthalate | 84-66-2 | sc-239738 sc-239738A | 25 ml 500 ml | $27.00 $33.00 | ||
Diethyl phthalate indirectly activates dcaR by influencing the bacterial response to phthalate esters. This involves the upregulation of dcaR expression, allowing it to modulate the transcriptional response to phthalate compounds in bacterial cells. | ||||||
2,4,6-Trichlorophenol | 88-06-2 | sc-209340 | 1 g | $275.00 | ||
2,4,6-Trichlorophenol acts as a direct activator of dcaR by binding to its regulatory region. This interaction enhances dcaR's ability to regulate genes involved in bacterial responses to chlorinated phenolic compounds, contributing to cellular detoxification. | ||||||
Cinnamic acid | 621-82-9 | sc-337631 | 1 g | $560.00 | ||
Cinnamic acid serves as a direct activator of dcaR by binding to its regulatory site. This interaction enhances dcaR's DNA-binding affinity, leading to the upregulation of genes involved in bacterial responses to cinnamic acid and related compounds. | ||||||