DC-SIGN Inhibitors
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) Inhibitors constitute a class of chemical compounds that specifically target a protein receptor known as DC-SIGN. DC-SIGN is primarily found on the surface of dendritic cells, a type of immune cell that plays a crucial role in initiating immune responses by capturing and presenting pathogens to other immune cells. It serves as a key player in the recognition and binding of various pathogens, including viruses, bacteria, and fungi, through interactions with carbohydrate structures on their surfaces. The role of DC-SIGN in pathogen recognition and immune activation makes it an attractive target for drug development, particularly in the context of infectious diseases. DC-SIGN Inhibitors are designed to interfere with the binding of pathogens to DC-SIGN, thereby disrupting the initial steps of infection and modulating immune responses.
Chemically, DC-SIGN Inhibitors encompass a diverse array of compounds, often designed through structure-based drug design or high-throughput screening approaches. These inhibitors typically feature functional groups and molecular structures that mimic the carbohydrate ligands recognized by DC-SIGN, effectively competing with pathogens for binding to the receptor. This competition can result in reduced pathogen attachment to dendritic cells and hinder their ability to initiate infection. By targeting DC-SIGN, these inhibitors provide insights into the molecular mechanisms of immune recognition and offer a basis for the development of novel strategies to combat infectious diseases. Moreover, as our understanding of DC-SIGN's involvement in immune processes continues to grow, DC-SIGN Inhibitors may find applications in a broader range of research areas, such as immunology and vaccine development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural phenol found in turmeric, may downregulate DC-SIGN expression by modulating NF-κB activity, a transcription factor involved in the regulation of immune responses and inflammatory processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound found in grapes and red wine, potentially inhibits DC-SIGN expression through its anti-inflammatory properties, impacting various signaling pathways including NF-κB. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
As a flavonoid with antioxidant properties, quercetin may influence DC-SIGN expression by modulating cellular redox states and interfering with signaling pathways involved in the inflammatory response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has potential to inhibit DC-SIGN expression through its anti-inflammatory and antioxidant activities, influencing various cellular processes and signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may impact DC-SIGN expression through its ability to activate NRF2, a transcription factor playing a key role in cellular defense against oxidative stress. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone from soy, potentially downregulates DC-SIGN expression by modulating estrogen receptor signaling and impacting various cellular processes involved in immune responses. | ||||||
Baicalin | 21967-41-9 | sc-204638 sc-204638A sc-204638B sc-204638C | 1 mg 25 mg 1 g 5 g | $55.00 $110.00 $220.00 $260.00 | 4 | |
Baicalin, a flavonoid found in the Chinese skullcap, may influence DC-SIGN expression through its anti-inflammatory properties, potentially modulating various signaling pathways including NF-κB. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Found in cruciferous vegetables, indole-3-carbinol may impact DC-SIGN expression by modulating estrogen metabolism and influencing various signaling pathways involved in immune responses and inflammation. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an alkaloid found in several plants, may downregulate DC-SIGN expression through its anti-inflammatory properties, potentially influencing various cellular processes and signaling pathways. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid, a polyphenol found in fruits and nuts, has potential to inhibit DC-SIGN expression through its antioxidant and anti-inflammatory activities, impacting various cellular processes. | ||||||