Cytokeratin 23 Inhibitors

Cytokeratins are a family of fibrous proteins that form the intermediate filaments within the cytoskeleton of epithelial cells. These proteins provide structural support and contribute to the mechanical integrity of epithelial tissues, including the skin, hair, and various internal organs. Cytokeratin 23, in particular, is one of the many isoforms within this protein family and is typically expressed in specific cell types, such as the epithelial cells of the esophagus and other stratified squamous epithelia.

Inhibitors of Cytokeratin 23 interact with this protein and potentially disrupt its filament-forming ability or affect its cellular functions. These inhibitors may operate through various mechanisms, such as binding to specific regions of Cytokeratin 23 or altering its conformation. By inhibiting Cytokeratin 23, these compounds can potentially impact the structural properties of epithelial cells and their ability to maintain tissue integrity. Research on Cytokeratin 23 inhibitors is primarily focused on unraveling the molecular functions of this particular cytokeratin isoform within epithelial tissues, providing insights into the complex organization and regulation of the cytoskeleton.