CysLT1 Receptor Activators
SEE ALSO...
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zafirlukast | 107753-78-6 | sc-204942 sc-204942A | 10 mg 100 mg | $36.00 $171.00 | 1 | |
Zafirlukast functions as a potent antagonist of the cysteinyl leukotriene receptor 1 (CysLT1), exhibiting unique molecular interactions that disrupt leukotriene signaling pathways. Its structure facilitates specific binding to the receptor, altering conformational dynamics and inhibiting downstream inflammatory responses. The compound's kinetic profile reveals a competitive inhibition mechanism, characterized by a notable affinity for the receptor, which influences its interaction with various cellular environments. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid is a precursor in the leukotriene synthesis pathway. Its metabolism by 5-lipoxygenase leads to the production of leukotrienes, which can activate CysLT1 receptors. | ||||||
5(S),6(R)-DiHETE | 82948-88-7 | sc-200421 sc-200421A | 50 µg 1 mg | $202.00 $2400.00 | ||
5(S),6(R)-DiHETE acts as an activator of the cysteinyl leukotriene receptor 1 (CysLT1), engaging in distinct molecular interactions that enhance receptor signaling. Its stereochemistry allows for precise binding, promoting conformational changes that trigger specific intracellular pathways. The compound exhibits unique reaction kinetics, facilitating rapid receptor activation and influencing downstream cellular responses, thereby modulating various physiological processes. | ||||||
Leukotriene E4 | 75715-89-8 | sc-201050 sc-201050A sc-201050B sc-201050C | 50 µg 1 mg 5 mg 10 mg | $207.00 $3570.00 $16320.00 $30600.00 | ||
Leukotriene A4, an intermediate in leukotriene biosynthesis, is converted into leukotriene C4, a known agonist of the CysLT1 receptor. This conversion indirectly enhances CysLT1 activation. | ||||||
(±)5-HETE | 73307-52-5 | sc-205136 sc-205136A sc-205136B | 25 µg 50 µg 100 µg | $89.00 $168.00 $319.00 | 1 | |
5-HETE, a metabolite of arachidonic acid, serves as a substrate for leukotriene synthesis. Its availability can indirectly increase the activation of CysLT1 by facilitating the production of leukotriene C4. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $240.00 $1275.00 | 40 | |
U46619, a thromboxane A2 analogue, can enhance the leukotriene pathway, indirectly leading to increased CysLT1 receptor activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
This compound increases intracellular calcium levels, which can enhance the activity of 5-lipoxygenase, leading to increased production of leukotrienes and indirect activation of CysLT1 receptors. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 can upregulate the leukotriene pathway, indirectly influencing CysLT1 receptor activation. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin can modulate the arachidonic acid pathway, leading to shifts in leukotriene production and indirect activation of CysLT1 receptors. | ||||||
MK-886 sodium salt | 118427-55-7 | sc-200608B sc-200608 sc-200608A | 1 mg 5 mg 25 mg | $46.00 $93.00 $371.00 | 3 | |
MK-886 inhibits 5-lipoxygenase-activating protein (FLAP), indirectly influencing leukotriene synthesis and CysLT1 receptor activation. | ||||||