CyPA Inhibitors
CyPA inhibitors belong to a class of chemical compounds that specifically target and inhibit the activity of the enzyme Cyclophilin A (CyPA). Cyclophilins are a family of peptidyl-prolyl isomerases, which catalyze the interconversion between cis and trans isomers of proline residues in peptide bonds. CyPA is a prominent member of this family and is known for its involvement in various cellular processes, particularly those related to protein folding, trafficking, and immune regulation. Structurally, CyPA inhibitors encompass a diverse range of molecules with distinct chemical scaffolds. These inhibitors are designed to interact with the active site of CyPA, which is essential for its enzymatic function. By binding to this site, CyPA inhibitors disrupt the isomerase activity of the enzyme, leading to the inhibition of proline isomerization in target proteins.
Several synthetic and naturally occurring compounds have been identified as CyPA inhibitors. Some of these compounds mimic the structure of the natural substrate of CyPA, allowing them to competitively bind to the enzyme's active site. Others work through non-competitive inhibition, where they bind to a distinct allosteric site, leading to conformational changes that hinder CyPA's enzymatic function. The discovery and development of CyPA inhibitors have been driven by their potential roles as research tools to probe the functional significance of CyPA in cellular processes. By selectively inhibiting CyPA, researchers can gain insights into its involvement in protein folding, intracellular trafficking, and immune response modulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Naphthoflavone | 604-59-1 | sc-257037 sc-257037A sc-257037B sc-257037C | 1 g 5 g 25 g 100 g | $34.00 $46.00 $156.00 $500.00 | 3 | |
α-Naphthoflavone is a synthetic compound that has been extensively studied as a potent and selective CYP1A inhibitor. It has been used in research to explore the role of CYP1A in drug metabolism and toxicology. | ||||||
Fluoranthene | 206-44-0 | sc-239999 | 5 g | $218.00 | ||
Fluoranthene is a polycyclic aromatic hydrocarbon and an environmental pollutant that has been identified as a CYP1A inhibitor. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine is a naturally occurring alkaloid that has exhibited anticancer properties. It is also known to inhibit CYP1A and can interfere with the metabolism of other drugs. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural compound found in grapes and certain other plants. It has been investigated for its inhibitory effects on CYP1A, potentially influencing drug interactions and metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenol present in turmeric, has been shown to inhibit CYP1A activity. Its impact on drug metabolism has been of interest in pharmacological research. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Fluconazole is an antifungal agent that has been identified as a CYP1A inhibitor. Its inhibitory effects can influence the metabolism of other drugs that are metabolized by CYP1A. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin is a natural anthraquinone derivative found in various plants. It has been studied for its inhibitory effects on CYP1A and its potential implications for drug metabolism. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole is a proton pump inhibitor used for gastric acid-related disorders. It has been found to inhibit CYP1A. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is an H2 receptor antagonist used to reduce stomach acid production. It has been identified as a CYP1A inhibitor, affecting the metabolism of certain drugs. | ||||||
Ticlopidine Hydrochloride | 53885-35-1 | sc-205861 sc-205861A | 1 g 5 g | $32.00 $99.00 | 2 | |
Ticlopidine is an antiplatelet agent commonly used to prevent blood clots. It has been reported to inhibit CYP1A, potentially influencing drug metabolism. | ||||||