CYP2A7 Activators
CYP2A7 Activators encompass a group of compounds that modulate the activity of the CYP2A7 enzyme, which is a lesser-known member of the cytochrome P450 monooxygenase family. This enzyme family is involved in the metabolism of a variety of endogenous and exogenous compounds through oxidative mechanisms.
Direct activators of CYP2A7 would likely bind to the enzyme, enhancing its catalytic action on specific substrates. This could be achieved by inducing a conformational change in the enzyme structure that results in a higher affinity for substrates or a more efficient electron transfer during the oxidation process. Indirect activators, on the other hand, may increase the activity of CYP2A7 by upregulating the expression of the gene, stabilizing the mRNA to increase protein translation, or by preventing the degradation of the enzyme, thus increasing its half-life. They might also influence the folding and post-translational modification processes that are crucial for the functional maturation of CYP2A7. Studies focusing on CYP2A7 and its activators can provide valuable insight into the complex network of interactions and regulations that govern metabolic pathways, particularly those involving the P450 enzymes. Insight into the mechanisms of action of CYP2A7 activators could contribute to a better understanding of how these enzymes can be modulated and the potential consequences of such modulation in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that enhances CYP2A7 activity by interacting with the enzyme and increasing its substrate binding and turnover. This compound increases the CYP2A7's ability to catalyze reactions involving its substrates. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol can enhance CYP2A7's activity by stabilizing its structure, thus improving its capacity to bind and metabolize substrates. This compound acts by binding to the enzyme, promoting its conformational stability and increasing its catalytic efficiency. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can increase the functional activity of CYP2A7. This compound is known to enhance the enzyme's ability to bind and metabolize its substrates, leading to increased enzymatic activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can enhance CYP2A7's activity by increasing the enzyme's stability and substrate affinity, thereby increasing its catalytic efficiency. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, enhances CYP2A7's activity by binding to the enzyme and increasing its substrate turnover. This compound has been shown to increase the enzymatic activity of CYP2A7 by promoting substrate binding and metabolism. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin can enhance CYP2A7's activity by promoting the enzyme's stability and substrate affinity, leading to increased catalytic efficiency. | ||||||
Diallyl sulfide | 592-88-1 | sc-204718 sc-204718A | 25 g 100 g | $42.00 $106.00 | 3 | |
Diallyl sulfide can enhance CYP2A7's activity by promoting the enzyme's stability and substrate affinity. This leads to increased catalytic efficiency and enhanced enzymatic activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a soy isoflavone, enhances CYP2A7's activity by increasing the enzyme's ability to bind and metabolize its substrates. This compound acts by promoting substrate binding and metabolism, leading to increased enzymatic activity. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin, a plant flavonoid, enhances CYP2A7's activity by increasing the enzyme's stability and substrate affinity. This leads to increased catalytic efficiency and enhanced enzymatic activity. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin enhances CYP2A7's activity by promoting the enzyme's stability and substrate affinity. This leads to increased catalytic efficiency and enhanced enzymatic activity. | ||||||