CYP19 Inhibitors
Items 11 to 18 of 18 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anastrozole-d12 | 120512-32-5 | sc-217649 | 1 mg | $278.00 | 1 | |
Anastrozole-d12 is a deuterated derivative that exhibits unique interactions with the CYP19 enzyme, enhancing its specificity in aromatase inhibition. The presence of deuterium alters the kinetic isotope effect, potentially influencing reaction rates and metabolic pathways. This compound's distinct isotopic labeling may also modify its affinity for enzyme-substrate complexes, leading to altered binding interactions. Furthermore, its physicochemical properties can affect solubility and permeability, impacting its overall behavior in biological systems. | ||||||
SDZ-089443 | sc-222300 sc-222300A | 10 mg 50 mg | $200.00 $409.00 | |||
SDZ-089443 is a selective inhibitor of CYP19, characterized by its unique binding affinity that alters the enzyme's conformation. This compound engages in specific molecular interactions that stabilize the enzyme-substrate complex, potentially enhancing its inhibitory efficacy. The presence of unique functional groups influences the reaction kinetics, leading to a distinct metabolic profile. Additionally, its solubility characteristics may facilitate differential distribution in various environments, affecting its overall reactivity. | ||||||
Exemestane | 107868-30-4 | sc-203045 sc-203045A | 25 mg 100 mg | $131.00 $403.00 | ||
Exemestane is a steroidal aromatase inactivator that irreversibly binds to the active site of aromatase, leading to its inactivation and preventing estrogen synthesis. | ||||||
α-Naphthoflavone | 604-59-1 | sc-257037 sc-257037A sc-257037B sc-257037C | 1 g 5 g 25 g 100 g | $33.00 $45.00 $153.00 $490.00 | 3 | |
α-Naphthoflavone acts as a selective modulator of CYP19, exhibiting a unique ability to interact with the enzyme's active site. Its planar structure allows for effective π-π stacking interactions, which can influence enzyme dynamics and substrate accessibility. This compound also alters the electron density around critical residues, impacting the catalytic efficiency. Furthermore, its hydrophobic characteristics may affect membrane permeability and localization within biological systems, influencing its overall metabolic behavior. | ||||||
R-(+)-Aminoglutethimide L-Tartrate Salt | 57344-88-4 | sc-208199 | 100 mg | $280.00 | ||
R-(+)-Aminoglutethimide L-Tartrate Salt functions as a potent modulator of CYP19, characterized by its ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This interaction stabilizes specific conformations, potentially altering the enzyme's catalytic pathway. Additionally, its chiral nature may influence stereoselectivity in metabolic processes, while its solubility properties can affect distribution and interaction with lipid membranes, further impacting its biochemical behavior. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole acts as a selective inhibitor of CYP19, engaging in unique hydrophobic interactions with the enzyme's active site. Its structural conformation allows for specific π-π stacking with aromatic residues, influencing the enzyme's substrate binding affinity. The compound's lipophilicity enhances its membrane permeability, potentially affecting its distribution in biological systems. Furthermore, Miconazole's kinetic profile suggests a competitive inhibition mechanism, modulating enzymatic activity through reversible binding dynamics. | ||||||
Fadrozole hydrochloride | 102676-31-3 | sc-252819 sc-252819A sc-252819B | 10 mg 50 mg 500 mg | $138.00 $530.00 $4080.00 | ||
Fadrozole is a nonsteroidal aromatase inhibitor that competes with androstenedione for binding to aromatase, inhibiting the conversion of androgens to estrogens. | ||||||
6-Methyleneandrost-4-ene-3,17-dione-19-d3 | sc-217366 | 1 mg | $430.00 | |||
6-Methyleneandrost-4-ene-3,17-dione-19-d3 exhibits a distinctive interaction with CYP19, characterized by its ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This compound's unique steric configuration facilitates a conformational change in CYP19, altering its catalytic efficiency. Additionally, its isotopic labeling enhances tracking in metabolic studies, providing insights into reaction pathways and enzyme kinetics. The compound's hydrophobic nature may also influence its solubility and interaction with lipid membranes, impacting its overall bioavailability. | ||||||