CYP19 Activators
Common CYP19 Activators include, but are not limited to Forskolin CAS 66575-29-9, Dexamethasone CAS 50-02-2, PGE2 CAS 363-24-6, Ghrelin (human) CAS 258279-04-8 and Bis(2-ethylhexyl) phthalate CAS 117-81-7.
CYP19 activators are compounds that stimulate the activity or expression of CYP19, commonly known as aromatase. Aromatase is a member of the cytochrome P450 superfamily of enzymes and plays a pivotal role in the biosynthesis of estrogens, the primary female sex hormones. Specifically, aromatase catalyzes the conversion of androgens (testosterone and androstenedione) into estrogens (estradiol and estrone), a transformation that occurs through a series of hydroxylation and demethylation reactions.
Located in various tissues, including the ovaries, placenta, adipose tissue, and brain, aromatase ensures the appropriate synthesis of estrogens, which are vital for a range of physiological processes, such as reproductive development, bone density maintenance, and neural function. The regulation of aromatase activity is complex and is influenced by various factors, including hormonal cues, tissue-specific promoters, and post-translational modifications. CYP19 activators, by enhancing the enzyme's activity or expression, can potentiate the synthesis of estrogens from androgenic precursors. Given the profound influence of estrogens on numerous physiological processes and the central role of aromatase in their synthesis, understanding the mechanisms by which CYP19 activators function offers deep insights into estrogen biology and the broader context of steroid hormone biosynthesis. Delving into the role of CYP19 activators underscores the intricate balance required for proper hormone synthesis, shedding light on the complex regulatory networks governing steroidogenesis and the multifaceted roles of estrogens in health and disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP can stimulate the promoter activity of CYP19, potentially leading to increased expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid can induce aromatase expression in certain tissues, like adipose tissue, by interacting with glucocorticoid response elements in the CYP19 gene promoter. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can upregulate aromatase expression by activating the cAMP-PKA pathway, leading to increased CYP19 promoter activity. | ||||||
Ghrelin (human) | 258279-04-8 | sc-364689 sc-364689A | 0.5 mg 1 mg | $186.00 $298.00 | 3 | |
Ghrelin, a peptide hormone, may upregulate aromatase expression in certain tissues, although the exact mechanism is not well-defined. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
BPA, an environmental endocrine disruptor, can stimulate aromatase expression, potentially through estrogen receptor-mediated mechanisms. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $57.00 | 2 | |
Certain phthalates have been shown to upregulate aromatase expression, potentially through activation of PPAR pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone found in soy, may induce aromatase expression in certain tissues, potentially through estrogenic activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A derivative of cAMP, 8-Br-cAMP can activate the cAMP pathway, leading to potential upregulation of CYP19 promoter activity and increased expression. | ||||||
3,3′,5,5′-Tetrabromobisphenol A | 79-94-7 | sc-238640 sc-238640A | 100 g 500 g | $82.00 $194.00 | 2 | |
TBBPA, a brominated flame retardant, can stimulate aromatase expression, possibly through interactions with estrogen receptors. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid, a fatty acid, can induce aromatase expression in certain cells, potentially through activation of specific signaling pathways. | ||||||