Linoleic Acid CAS: 60-33-3
MF: C18H32O2
MW: 280.44
A fatty acid with cytotoxic activity that influences the inflammatory process.

Linoleic Acid (CAS 60-33-3)

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同義語 Telfairic Acid; 9-cis,12-cis-Octadecadienoic acid
アプリケーション: A fatty acid with cytotoxic activity that influences the inflammatory process
CAS 番号: 60-33-3
Purity: ≥99%
Molecular Weight: 280.44
Molecular Formula: C18H32O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Linoleic Acid is a fatty acid that has been observed to influence the inflammatory process and regulate the functions of neutrophils. Research has demonstrated that Linoleic Acid has cytotoxic activity and induces cell apoptosis by augmenting cellular oxidant status and inducing mitochondrial dysfunction. Additionally, the compound has been shown to stimulate the growth of MDA-MB-231 cells, increase the production of thromboxanes and prostaglandins, and reduce the levels of HHT and HETE. Linoleic Acid is an activator of PPAR.


参考文献

1. Srivastava, K.C., et al. 1982. Prostaglandins Leukot Med. 9: 669-684. PMID: 6818563
2. Rose, D.P., et al. 1994. Cancer Res. 54: 6557-6562. PMID: 7987856
3. Rodrigues, H.G., et al. 2010. Lipids. 45: 809-819. PMID: 20730605
4. Lu, X., et al. 2010. Lipids Health Dis. 9: 106. PMID: 20868498

Physical State :
Liquid
Solubility :
Soluble in DMSO, ethanol, ether, acetone, and benzene. Insoluble in water.
保存方法 :
Store at -20° C
Melting Point :
-5° C (lit.)
Boiling Point :
229-230° C (lit.) at 16 mmHg
Density :
0.90 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.47 (lit.)
IC50 :
GPR40: EC5050 = 0.54 µM; COX1: IC50 = 13 µM; LO1: IC50 = 1 µM (soybean)
pK Values :
pKa: 4.77
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
1
RTECS :
RF9990000
PubChem CID :
5280450
Merck Index :
14: 5505
MDL Number :
MFCD00064241
EC Number :
200-470-9
Beilstein Registry :
1727101
SMILES :
CCCCCC=CCC=CCCCCCCCC(=O)O

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Linoleic Acid  参考文献

See how others have used Linoleic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28973946  Lopez, MS. et al. 2017. Proc. Natl. Acad. Sci. U.S.A. 114: 11223-11228.

PMID: # 15170673  Kohno, H. et al. 2004. Int. J. Cancer. 110: 896-901.

PMID: # 32157714  J. Food Biochem. e13177.

Citations 1 to 3 of 3 total
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