CYP11A1 Activators
CYP11A1 activators represent a diverse collection of chemicals that share the capacity to stimulate expression of the cytochrome P450 enzyme CYP11A1. As a class, these activators span different chemical types including steroids, industrial compounds, and environmental contaminants. A common attribute of many CYP11A1 activators is their ability to engage nuclear receptors that regulate CYP11A1 gene transcription. Binding of an activator to receptors like the glucocorticoid receptor, estrogen receptor, pregnane X receptor, constitutive androstane receptor, or peroxisome proliferator-activated receptors initiates intracellular signaling cascades that mobilize transcription factors and transcriptional co-regulators. These proteins then interact with hormone response elements in regulatory sequences of the CYP11A1 gene to enhance recruitment of RNA polymerase and elevate the production of CYP11A1 mRNA transcripts.
Alternatively, some CYP11A1 activators are thought to wield indirect effects through disruption of cellular processes regulating gene expression.They may perturb signaling networks, epigenetic machinery, or basic homeostatic pathways in a manner that secondarily modulates receptor signaling cross-talk or the function of DNA binding proteins governing CYP11A1 transcriptional controls. Through diverse direct and indirect mechanisms functioning at the level of gene regulation, this motley collection of chemicals collectively serves to boost CYP11A1 expression levels in target tissues where it is found.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that induces expression of CYP11A1 through direct binding and activation of glucocorticoid receptors which then interact with glucocorticoid response elements in the promoter region of the CYP11A1 gene. | ||||||
Di-n-butyl phthalate | 84-74-2 | sc-257307 sc-257307A sc-257307B | 5 g 25 g 1 kg | $41.00 $52.00 $104.00 | 1 | |
Di-n-butyl phthalate phthalate is an endocrine disruptor that may upregulate CYP11A1 gene transcription by binding to and activating peroxisome proliferator-activated receptors that heterodimerize with retinoid X receptors at response elements in the CYP11A1 gene. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin signaling and modulates some transcription factors resulting in increased levels of CYP11A1 mRNA as part of the immunosuppressive effects in tissues where it is expressed. | ||||||
Methoxychlor | 72-43-5 | sc-253009 | 100 mg | $36.00 | ||
Methoxychlor is an organochlorine pesticide with estrogenic properties that may stimulate CYP11A1 transcription through activation of intracellular estrogen receptors and their interaction with cognate response elements in the CYP11A1 gene proximal promoter region. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is an environmental endocrine disruptor that mimics estrogen and may induce CYP11A1 expression levels by binding to and activating estrogen receptors that regulate transcriptional activity of estrogen response elements in the CYP11A1 gene. | ||||||
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
5,5-Diphenyl Hydantoin activates transcription factors involved in cellular signaling processes and is thought to stimulate CYP11A1 upregulation indirectly by modulating transcription factor interactions with regulatory regions of the CYP11A1 gene. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid alters histone deacetylase activity resulting in chromatin remodeling and differential binding of regulatory proteins to response elements in the promoter region of CYP11A1 leading to increased gene transcription. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
(±)-Menthol may induce expression of CYP11A1 through mechanisms involving receptor-mediated intracellular signaling and alterations in transcription factor activity that augment CYP11A1 gene transcription regulated through its promoter region. | ||||||