Date published: 2025-10-1

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cyclin E Inhibitors

Cyclin E inhibitors constitute a significant chemical class with crucial implications in cell cycle regulation. These compounds interact intricately with cyclin E, a key protein involved in cell cycle progression. Cyclin E forms a complex with cyclin-dependent kinases (CDKs), orchestrating the transition from G1 phase to S phase in the cell cycle. The inhibitors targeting cyclin E function by impeding the binding of cyclin E to its corresponding CDK partner, thereby interrupting the initiation of DNA replication. This interference halts the progression of the cell cycle at a pivotal checkpoint, serving as a regulatory mechanism to prevent uncontrolled cell division and maintain genomic stability. The molecular structure of cyclin E inhibitors typically features distinct functional groups that engage with the binding sites of cyclin E and CDK. These inhibitors exert their effects through a competitive inhibition mechanism, where they vie with cyclin E for binding to the CDK active site. By obstructing this interaction, cyclin E inhibitors play a pivotal role in modulating the orderly progression of the cell cycle. Their influence extends beyond a single phase, as the cell cycle requires meticulous coordination of various checkpoints to ensure accurate DNA replication and cell division. In essence, cyclin E inhibitors act as molecular brakes, restraining the cell cycle machinery at specific stages and helping to prevent aberrant proliferation that could have wide-ranging implications for cellular health.

Items 1 to 10 of 21 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$92.00
$260.00
42
(2)

Ribociclib is another cyclin-dependent kinase (CDK) 4/6 inhibitor used to treat hormone receptor-positive, HER2-negative breast cancer. It helps control cell division and proliferation.

Palbociclib

571190-30-2sc-507366
50 mg
$315.00
(0)

Palbociclib inhibits cyclin E, thereby disrupting cell cycle progression.

Kenpaullone

142273-20-9sc-200643
sc-200643A
sc-200643B
sc-200643C
1 mg
5 mg
10 mg
25 mg
$60.00
$150.00
$226.00
$495.00
1
(1)

Kenpaullone (CAS 142273-20-9) is a chemical compound that acts as a potent inhibitor of cyclin E. It plays a regulatory role in cell cycle progression.

10Z-Hymenialdisine

82005-12-7sc-360987
500 µg
$210.00
(1)

10Z-Hymenialdisine (CAS 82005-12-7) is a chemical compound known for its role as a cyclin E inhibitor. It affects cellular processes by interacting with cyclin E, a key regulator in cell cycle progression. The compound's impact on cyclin E function contributes to its relevance in cell cycle research and related studies.

Ribociclib

1211441-98-3sc-507367
10 mg
$450.00
(0)

Ribociclib is another cyclin-dependent kinase (CDK) 4/6 inhibitor used for hormone receptor-positive, HER2-negative breast cancer. It helps control cell division and proliferation.

Indirubin

479-41-4sc-201531
sc-201531A
5 mg
25 mg
$112.00
$515.00
4
(1)

Indirubin (CAS 479-41-4) acts as a cyclin E inhibitor, influencing cellular processes. It modulates cyclin E-associated activities without clinical connotations.

Aminopurvalanol A

220792-57-4sc-223775
sc-223775A
1 mg
5 mg
$51.00
$118.00
(1)

Aminopurvalanol A (CAS 220792-57-4) is a chemical compound known for its role as a cyclin E inhibitor. It interacts with the cyclin E protein, modulating its activity and impacting cell cycle progression. This compound's mechanism of action offers insights into cellular processes involving cyclin E regulation.

Cdk4 Inhibitor Inhibitor

546102-60-7sc-203873
1 mg
$134.00
5
(1)

CDK4 Inhibitor (CAS 546102-60-7) targets cyclin E function by inhibiting CDK4 activity, affecting cell cycle progression.

Abemaciclib

1231929-97-7sc-507342
10 mg
$110.00
(0)

Abemaciclib is a CDK4/6 inhibitor that interferes with cyclin E and other proteins involved in cell cycle regulation.

AZD 5438

602306-29-6sc-361115
sc-361115A
10 mg
50 mg
$205.00
$865.00
(0)

AZD 5438 (CAS 602306-29-6) is a chemical compound that functions as a cyclin E inhibitor. It impacts cell cycle regulation by targeting cyclin E, without involving clinical or therapeutic aspects.