CstF-64 Activators

The term CstF-64 Activators in this context refers to compounds that indirectly influence the function of CstF-64, a protein essential in the 3'-end cleavage and polyadenylation of pre-mRNA. Direct chemical activation of CstF-64 is not a well-established concept due to the complex nature of RNA processing and the protein's role in these processes. However, modulation of transcription, RNA processing, and related cellular signaling pathways provides a strategy for indirectly influencing CstF-64 activity. Compounds like α-Amanitin, DRB, and Actinomycin D, which affect RNA polymerase II activity and transcription elongation, can have downstream effects on mRNA processing involving CstF-64. Cordycepin, which inhibits RNA polyadenylation, is directly relevant to the processes regulated by CstF-64.

Leptomycin B and Triptolide, affecting nuclear export of RNA and transcription respectively, can indirectly impact CstF-64's function in mRNA maturation. Flavopiridol, as a CDK inhibitor, and U0126, a MEK inhibitor, may influence signaling pathways that regulate transcription and, subsequently, CstF-64 activity. JQ1, by modulating the activity of BET bromodomains, can influence transcriptional dynamics, potentially affecting CstF-64. Curcumin and Trichostatin A, through their broad biological activities, can indirectly impact pathways related to mRNA processing. BAY 11-7082, an inhibitor of NF-κB activation, is included due to its potential influence on signaling pathways that could intersect with CstF-64's role in mRNA processing.