CSPP1 Inhibitors
Chemical inhibitors of CSPP1 can target the protein through various disruptions in microtubule dynamics and mitotic spindle assembly processes. Blebbistatin acts by inhibiting myosin II ATPase activity, which is crucial for mitotic spindle assembly, a process where CSPP1 plays a significant role. With the spindle assembly compromised, CSPP1's function is indirectly inhibited as the proper spindle function is integral to its role in cell division. Similarly, nocodazole, which depolymerizes microtubules, and colchicine, which prevents microtubule polymerization, can disrupt the microtubule dynamics essential for CSPP1's operations. Taxol and paclitaxel, on the other hand, stabilize microtubules excessively, preventing the dynamic changes required for CSPP1's action during cell division, leading to its functional inhibition.
Vincristine and Vinblastine further contribute to the inhibition of CSPP1 by binding to tubulin, inhibiting microtubule formation, and thus preventing the organization of microtubules and mitotic spindles where CSPP1 is essential. Eribulin's unique mechanism of inhibiting microtubule growth without affecting shortening disrupts microtubule networks, which are necessary for CSPP1's function. Monastrol and S-Trityl-L-cysteine target the kinesin Eg5, a protein vital for spindle bipolarity, and by inhibiting Eg5, these chemicals can disrupt mitotic spindle organization and function, thereby impairing CSPP1 activity. Kinesore, although lacking a CAS number, similarly inhibits the kinesin-5 motor protein, affecting spindle dynamics. Griseofulvin adds to this list by disrupting mitotic spindles through microtubule interaction, further leading to the functional inhibition of CSPP1 by destabilizing the microtubule dynamics essential for CSPP1's localization and function during cell division.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is an inhibitor of myosin II ATPase activity. As CSPP1 has been implicated in spindle orientation during cell division, and myosin II is instrumental in mitotic spindle assembly and function, blebbistatin can indirectly inhibit CSPP1 by disrupting proper spindle function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that disrupts microtubule dynamics. CSPP1 is involved in microtubule organization, and its inhibition through nocodazole can prevent proper CSPP1-mediated spindle assembly and microtubule stabilization during cell division. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and prevents their disassembly, which can interfere with microtubule dynamics necessary for CSPP1 function during mitotic spindle organization, thereby functionally inhibiting CSPP1. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits microtubule polymerization. By destabilizing microtubules, colchicine can prevent CSPP1 from fulfilling its role in microtubule organization and mitotic spindle assembly, leading to functional inhibition of CSPP1. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule assembly. Inhibiting microtubule assembly can functionally inhibit CSPP1 by disrupting the microtubule dynamics necessary for its role in cell division and spindle orientation. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, leading to dysfunctional microtubule networks. This can indirectly inhibit CSPP1 by preventing the proper formation and organization of microtubules that CSPP1 interacts with. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a specific inhibitor of the kinesin Eg5 which is essential for spindle bipolarity. By inhibiting Eg5, monastrol can indirectly inhibit CSPP1 by disrupting the mitotic spindle organization in which CSPP1 is involved. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts mitotic spindle formation by interacting with microtubules. This can lead to functional inhibition of CSPP1 through the destabilization of microtubule dynamics that are essential for the localization and function of CSPP1 during cell division. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a synthetic inhibitor of Eg5, a kinesin involved in spindle pole separation. By inhibiting Eg5, it can indirectly inhibit CSPP1 by preventing correct spindle assembly and function, a cellular process where CSPP1 is known to be an essential component. | ||||||