CRTAC1 Activators
CRTAC1 activators refer to a spectrum of compounds that target and modulate the activity of cartilage acidic protein 1 (CRTAC1). As a protein expressed in cartilaginous tissues, CRTAC1 is implicated in the extracellular matrix's structural integrity and homeostasis, although the complete biological functions of CRTAC1 are not fully characterized. Research suggests that CRTAC1 might play a role in the maintenance of cartilage tissue and possibly in chondrocyte function.
Direct activators of CRTAC1 are likely to interact with the protein in a way that enhances its stability or promotes its interaction with other components of the extracellular matrix. This might involve the binding of these activators to specific domains of CRTAC1, potentially leading to a conformational change that could increase its activity or prevent its degradation, thus maintaining the integrity of the extracellular matrix within cartilaginous tissues. Indirect activators may operate by affecting the expression levels of the CRTAC1 gene, thereby increasing the protein's synthesis and accumulation in the extracellular matrix. Alternatively, they could influence post-translational modifications of CRTAC1, such as glycosylation patterns, which may affect its function and interactions within the matrix. Indirect activators could also modulate the signaling pathways that regulate the deposition or breakdown of extracellular matrix components, thereby indirectly affecting CRTAC1 function.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $20.00 $28.00 $42.00 $82.00 $683.00 | 1 | |
Sodium Bicarbonate can increase the pH levels in the cellular environment. CRTAC1 is known to function in pH regulation, hence, the increased pH levels can lead to the activation of CRTAC1. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium Chloride can increase the levels of free calcium ions in the cell. Increased calcium levels can bind to CRTAC1, triggering a conformational change and thus, activating the protein. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium Sulfate can increase the intracellular levels of magnesium ions which are co-factors for many enzymes involved in the biosynthesis of cartilage, the tissue where CRTAC1 is highly expressed. Thus, increased magnesium levels can enhance the CRTAC1 activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic Acid is a known stimulant of collagen synthesis, a process where CRTAC1 is heavily involved. Enhanced collagen synthesis can lead to increased CRTAC1 activity. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $48.00 $179.00 $310.00 $96.00 | 3 | |
Sodium Selenite is a source of selenium that is necessary for the function of several selenium-dependent enzymes involved in cartilage synthesis, thereby indirectly enhancing the activity of CRTAC1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can stimulate the synthesis of extracellular matrix proteins in chondrocytes, where CRTAC1 is known to be active. Thus, dexamethasone can indirectly enhance the activity of CRTAC1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid regulates the differentiation of chondrocytes, where CRTAC1 is expressed. This can lead to increased activity of CRTAC1. | ||||||
β-Glycerophosphate disodium salt | 819-83-0 | sc-220452 sc-220452A sc-220452B sc-220452C sc-220452D sc-220452E | 25 g 100 g 500 g 1 kg 3 kg 6 kg | $62.00 $117.00 $433.00 $724.00 $2050.00 $3580.00 | 43 | |
Beta-Glycerophosphate is involved in phosphate metabolism. Increased phosphate levels can stimulate the activity of CRTAC1, given its involvement in cartilage mineralization. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $34.00 $73.00 | 2 | |
Thyroxine is known to stimulate cartilage growth, which can indirectly lead to increased CRTAC1 activity, considering its significant expression in cartilage tissue. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Hydrocortisone can stimulate the synthesis of extracellular matrix proteins in chondrocytes, thereby indirectly enhancing the activity of CRTAC1. | ||||||