CRP2 Activators
The category of CRP2 Activators encompasses a variety of chemicals that can indirectly influence the function of the CSRP2 protein by modulating related signaling pathways or cellular processes. A common mechanism shared by many of these activators involves the elevation of cyclic AMP (cAMP) levels within the cell. This is achieved by either activating adenylate cyclase through chemicals such as Forskolin, Epinephrine, and Isoproterenol, or by inhibiting phosphodiesterases, the enzymes that degrade cAMP, through chemicals like IBMX and Rolipram. The increase in cAMP levels activates Protein Kinase A (PKA), which can then phosphorylate and activate CSRP2.
Another group of chemicals within this category, including Bt2cAMP, BAY 73-4506 (Regorafenib), LY294002, and Staurosporine, act either by directly activating PKA or by inhibiting kinases that negatively regulate the cAMP-PKA signaling pathway. This results in the promotion of CSRP2 activation. A further intriguing aspect of this category is the inclusion of chemicals like Okadaic acid and Calyculin A, which inhibit protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, the overall phosphorylation state of proteins can be increased, which can lead to CSRP2 activation. Therefore, the CRP2 Activators encompass a range of chemicals that can manipulate the activity of CSRP2 through distinct mechanisms, primarily involving the alteration of phosphorylation states via the cAMP-PKA signaling pathway or through the inhibition of protein phosphatases.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases the cellular levels of cyclic AMP (cAMP). Elevated cAMP levels can activate PKA (Protein Kinase A), a kinase that can phosphorylate and activate various proteins, including CSRP2. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates the beta-adrenergic receptors, which can stimulate adenylate cyclase. This leads to an increase in cAMP levels, and subsequently activates PKA, which can phosphorylate and activate CSRP2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases (PDEs), enzymes that degrade cAMP. By inhibiting PDEs, IBMX can increase cAMP levels, leading to PKA activation and subsequent CSRP2 phosphorylation and activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective PDE4 inhibitor. By inhibiting PDE4, Rolipram increases cAMP levels, which can activate PKA, leading to CSRP2 phosphorylation and activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Bt2cAMP is a membrane-permeable cAMP analog that activates PKA directly. The activation of PKA can lead to phosphorylation and activation of CSRP2. | ||||||
Regorafenib | 755037-03-7 | sc-477163 sc-477163A | 25 mg 50 mg | $320.00 $430.00 | 3 | |
Regorafenib is a multi-kinase inhibitor, but it can indirectly activate CSRP2 by inhibiting kinases that negatively regulate cAMP-PKA signaling, promoting CSRP2 phosphorylation and activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, it can increase the phosphorylation state of proteins, potentially including CSRP2. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases PP1 and PP2A. Similar to okadaic acid, by inhibiting these phosphatases, it can increase protein phosphorylation, potentially activating CSRP2. | ||||||