CRM1 Activators

Common CRM1 Activators include, but are not limited to Actinomycin D CAS 50-76-0, Camptothecin CAS 7689-03-4, Hydroxyurea CAS 127-07-1, Doxorubicin CAS 23214-92-8 and Fluorouracil CAS 51-21-8.

CRM1, also known as Exportin 1 (XPO1), is a protein that plays a vital role in the nucleocytoplasmic transport of proteins and RNA. It is a member of the karyopherin family and specifically functions as a receptor for the nuclear export signals (NES) found on many proteins. CRM1 recognizes these NES motifs and, with the assistance of RanGTP, facilitates the transport of cargo proteins from the nucleus to the cytoplasm, a process essential for maintaining proper cellular function. The proper shuttling of molecules between the nucleus and cytoplasm is crucial for regulating protein localization, modulating gene expression, and maintaining cellular homeostasis. CRM1's role in this transport process underscores its importance in a variety of cellular processes.

CRM1 Activators represents a category of molecules that enhance or stimulate the activity or expression of the CRM1 protein. By promoting the function of CRM1, these activators can amplify the nucleocytoplasmic transport of specific cargo proteins, effectively reshaping the cellular landscape of protein distribution between the nucleus and cytoplasm. Mechanistically, CRM1 activators may act by enhancing the protein's affinity for NES motifs or by modulating the CRM1-RanGTP interaction, ensuring a more efficient transport process.