Date published: 2025-12-10

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CRM Inhibitors

Santa Cruz Biotechnology now offers a broad range of CRM Inhibitors for use in various applications. CRM, or Chromatin Remodeling, is a crucial process involved in the regulation of gene expression by altering the structure of chromatin to either facilitate or inhibit access to DNA. CRM Inhibitors are essential tools in scientific research for studying the mechanisms of gene regulation, understanding the dynamics of chromatin structure, and exploring the epigenetic factors that influence cellular function. These inhibitors allow researchers to dissect the role of specific chromatin remodeling complexes in various biological processes, including DNA replication, repair, and transcriptional regulation. By inhibiting chromatin remodeling, scientists can investigate how changes in chromatin accessibility affect gene expression patterns and contribute to cellular differentiation, development, and disease. CRM Inhibitors are widely used in studies focused on the epigenetic regulation of gene expression, providing insights into how chromatin structure and function are modulated in response to different physiological and environmental stimuli. The availability of these inhibitors has significantly advanced research in fields such as molecular biology, genetics, and cancer research, offering critical tools for unraveling the complex regulatory networks that control gene expression. By enabling precise modulation of chromatin remodeling activity, CRM Inhibitors have become indispensable for exploring the fundamental mechanisms that govern cellular identity and function. View detailed information on our available CRM Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Leptomycin B

87081-35-4sc-358688
sc-358688A
sc-358688B
50 µg
500 µg
2.5 mg
$105.00
$408.00
$1224.00
35
(2)

Leptomycin B functions as a CRM by selectively inhibiting nuclear export through its interaction with the exportin-1 protein. This compound forms a stable complex with exportin-1 and its cargo, preventing the translocation of proteins from the nucleus to the cytoplasm. Its unique mechanism disrupts cellular transport processes, leading to altered gene expression and protein localization. The compound's specificity for this pathway highlights its role in regulating cellular dynamics and maintaining nuclear integrity.

Leptomycin B, Free Acid

87081-35-4sc-202210
sc-202210A
100 µg
500 µg
$196.00
$689.00
10
(0)

Leptomycin B, Free Acid exhibits unique properties as a CRM by modulating the interaction between proteins and the nuclear pore complex. It disrupts the binding of exportin-1 to its cargo, effectively blocking the nuclear export pathway. This interference alters the kinetics of protein localization, influencing cellular signaling and homeostasis. Its distinct ability to target specific protein interactions underscores its role in fine-tuning intracellular transport mechanisms.

Verdinexor

1392136-43-4sc-492602
5 mg
$395.00
(0)

Verdinexor functions as a CRM by selectively inhibiting the nuclear export of proteins through its interaction with exportin-1. This compound alters the conformational dynamics of the exportin-cargo complex, leading to a significant delay in the nuclear export process. Its unique binding affinity and specificity for certain protein motifs enable it to modulate cellular pathways, impacting gene expression and protein stability. This nuanced interaction highlights its role in regulating intracellular transport and signaling networks.