| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B functions as a CRM by selectively inhibiting nuclear export through its interaction with the exportin-1 protein. This compound forms a stable complex with exportin-1 and its cargo, preventing the translocation of proteins from the nucleus to the cytoplasm. Its unique mechanism disrupts cellular transport processes, leading to altered gene expression and protein localization. The compound's specificity for this pathway highlights its role in regulating cellular dynamics and maintaining nuclear integrity. | ||||||
Leptomycin B, Free Acid | 87081-35-4 | sc-202210 sc-202210A | 100 µg 500 µg | $196.00 $689.00 | 10 | |
Leptomycin B, Free Acid exhibits unique properties as a CRM by modulating the interaction between proteins and the nuclear pore complex. It disrupts the binding of exportin-1 to its cargo, effectively blocking the nuclear export pathway. This interference alters the kinetics of protein localization, influencing cellular signaling and homeostasis. Its distinct ability to target specific protein interactions underscores its role in fine-tuning intracellular transport mechanisms. | ||||||
Verdinexor | 1392136-43-4 | sc-492602 | 5 mg | $395.00 | ||
Verdinexor functions as a CRM by selectively inhibiting the nuclear export of proteins through its interaction with exportin-1. This compound alters the conformational dynamics of the exportin-cargo complex, leading to a significant delay in the nuclear export process. Its unique binding affinity and specificity for certain protein motifs enable it to modulate cellular pathways, impacting gene expression and protein stability. This nuanced interaction highlights its role in regulating intracellular transport and signaling networks. | ||||||