CPAMD8 Inhibitors
CPAMD8 Inhibitors comprise a group of chemical compounds that target specific proteases or cellular processes to indirectly inhibit the functional activity of CPAMD8. For instance, E64 and E-64d are cysteine protease inhibitors that can prevent the proteolytic activity that CPAMD8 may rely on for its function. By inhibiting the degradation of extracellular matrix components, these inhibitors could reduce the bioavailability of substrates necessary for CPAMD8's activity. Similarly, leupeptin and AEBSF target serine and cysteine proteases, potentially reducing CPAMD8 activity by preventing the proteolytic processing essential for its function.
Other compounds such as lactacystin and MG132 inhibit the ubiquitin-proteasome system, which could decrease CPAMD8 activity by preventing the degradation of regulatory proteins that control CPAMD8's function. This wouldresult in the accumulation of such proteins, leading to a reduction in CPAMD8 activity. Moreover, MDL-28170's calpain inhibitory effect might also modulate CPAMD8, provided that CPAMD8 is subject to calpain-mediated proteolytic events. In addition to protease inhibition, specific inhibitors like alantolactone and Withaferin A target signaling pathways such as NF-κB. The inhibition of NF-κB by these compounds could lead to decreased CPAMD8 activity if CPAMD8 is upregulated by NF-κB signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64d is an epoxysuccinyl peptide and a derivative of E64, which is also a potent inhibitor of cysteine proteases. It would decrease CPAMD8 activity by inhibiting cysteine proteases that may be involved in the activation or function of CPAMD8. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is a reversible inhibitor of serine and cysteine proteases. By inhibiting these protease families, CPAMD8's proteolytic activity, if it involves serine and cysteine proteases, would be reduced due to the inhibition of proteolytic processing needed for its function. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. If CPAMD8's function is regulated by protein turnover via the ubiquitin-proteasome system, lactacystin would prevent the degradation of regulatory proteins, thus inhibiting CPAMD8 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a peptide aldehyde that inhibits the proteasome and calpains. It would lead to reduced CPAMD8 activity by preventing the degradation of CPAMD8 regulatory proteins that are normally targeted by the ubiquitin-proteasome system. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
AEBSF is an irreversible inhibitor of serine proteases. If CPAMD8 is activated or regulated by serine protease activity, the inhibition of these enzymes by AEBSF would decrease CPAMD8 activity. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $156.00 $260.00 $640.00 $1186.00 $2270.00 | 3 | |
Chymostatin is a chymotrypsin inhibitor that also affects other proteolytic enzymes. If CPAMD8's function requires the activity of chymotrypsin-like enzymes, chymostatin would inhibit these enzymes and thereby decrease CPAMD8 activity. | ||||||
MDL-28170 | 88191-84-8 | sc-201301 sc-201301A sc-201301B sc-201301C | 10 mg 50 mg 100 mg 500 mg | $69.00 $241.00 $447.00 $2195.00 | 20 | |
MDL-28170 is a calpain inhibitor that can cross the blood-brain barrier. By inhibiting calpains, it could reduce CPAMD8 activity if CPAMD8 is modulated by calpain-mediated proteolytic events. | ||||||
Alantolactone | 546-43-0 | sc-480981 | 5 mg | $380.00 | ||
Alantolactone is a sesquiterpene lactone that inhibits the NF-κB pathway. If CPAMD8 activity is upregulated by NF-κB signaling, inhibition of this pathway by alantolactone would result in decreased CPAMD8 activity. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a steroidal lactone that inhibits the NF-κB pathway. Similar to alantolactone, it would decrease CPAMD8 activity by inhibiting NF-κB signaling, which may upregulate CPAMD8's function. | ||||||