COPA Activators
COPA activators are a diverse class of chemical compounds that directly or indirectly enhance the functional activity of COPA. These activators primarily target the Golgi apparatus and disrupt its structure, leading to the activation of COPA and its involvement in the retrograde transport pathway. Examples of COPA activators include Brefeldin A, Monensin, and Golgicide A. Brefeldin A inhibits the ARF1 pathway, leading to the accumulation of COPA on the Golgi apparatus and enhancing its functional activity. Monensin alters the intracellular pH and disrupts the Golgi apparatus, activating COPA in the process. Golgicide A specifically targets the Golgi matrix protein GM130, disrupting the Golgi structure and enhancing COPA activity.
Additionally, other COPA activators, such as Golgi disruptor 58 and Nocodazole, disrupt microtubule dynamics or target Golgi-associated proteins,such as GRASP1, GOLPH3, GMAP-210, GRASP65, golgin-97, and golgin-84, leading to Golgi disruption and increased COPA activity. These chemical compounds collectively enhance the functional activity of COPA by directly or indirectly modulating specific signaling pathways and biological processes involved in the retrograde transport pathway. Overall, COPA activators exert their effects by altering the Golgi apparatus, either through disruption of its structure or modulation of associated proteins. This activation of COPA enhances its functional activity in the retrograde transport pathway, allowing for efficient protein trafficking within the cell. The diverse range of chemical compounds that act as COPA activators provides valuable tools for studying and manipulating intracellular protein transport processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore antibiotic that enhances the functional activity of COPA by altering the intracellular pH and disrupting the Golgi apparatus. This disruption leads to the activation of COPA and its involvement in the retrograde transport of proteins. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it indirectly enhances the functional activity of COPA by altering the pH of intracellular compartments and promoting the retrograde transport mediated by COPA. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that indirectly enhances the functional activity of COPA by disrupting microtubule dynamics. This disruption leads to the activation of COPA and its involvement in the retrograde transport of proteins. | ||||||