COL6A3 Activators
The chemicals listed above can be classified as indirect activators or modulators of COL6A3, as they do not directly interact with the collagen protein but influence its synthesis, stability, or degradation. These activators primarily function by modulating the biochemical pathways and cellular processes that are critical for collagen production and maintenance within the extracellular matrix. For example, Ascorbic Acid (Vitamin C) is a well-known cofactor for the hydroxylase enzymes necessary for the post-translational modification of collagen, including COL6A3. Copper and Manganese serve as essential cofactors for enzymes like lysyl oxidase and hydroxylases that play vital roles in collagen cross-linking and stability. Transforming Growth Factor-Beta (TGF-β) is a cytokine that can upregulate the expression of collagen genes, thereby potentially increasing COL6A3 levels.
In contrast, compounds like β-Aminopropionitrile and D-Penicillamine act as inhibitors of collagen cross-linking, affecting the physical properties and function of collagen fibers, including those containing COL6A3. Ethanol, Curcumin, and Hydroxychloroquine, through various mechanisms, can alter collagen synthesis and degradation, thereby influencing COL6A3 levels and ECM integrity. Additionally, Matrix Metalloproteinase (MMP) Inhibitors such as Marimastat help maintain ECM structure by preventing the breakdown of collagen, which indirectly supports COL6A3 stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid is essential for collagen synthesis, including COL6A3, by acting as a cofactor for prolyl and lysyl hydroxylase enzymes. | ||||||
Thymosin β4 | 77591-33-4 | sc-396076 sc-396076A | 1 mg 100 mg | $134.00 $7140.00 | ||
TGF-β can upregulate the expression of various collagen types, potentially influencing COL6A3 levels. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper is a cofactor for lysyl oxidase, an enzyme involved in collagen cross-linking, which may affect COL6A3 stability and function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate collagen gene expression, potentially influencing COL6A3 synthesis. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
Manganese is a cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes critical for collagen synthesis, impacting COL6A3. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $45.00 $94.00 | ||
D-Penicillamine can interfere with collagen cross-linking, potentially affecting COL6A3 stability and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate collagen synthesis and degradation, potentially affecting COL6A3 expression. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine affects lysosomal function and may influence collagen degradation, potentially impacting COL6A3. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine has been shown to affect collagen synthesis and metabolism, potentially influencing COL6A3 levels. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
MMP inhibitors prevent the breakdown of extracellular matrix components, potentially affecting COL6A3 turnover. | ||||||