Date published: 2025-10-15

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CLN8 Inhibitors

CLN8 Inhibitors comprise a specialized chemical class of compounds that have been investigated for their potential to selectively modulate the activity of Ceroid Lipofuscinosis, Neuronal 8 (CLN8) protein. CLN8 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) and lysosomes. Mutations in the CLN8 gene can lead to a group of neurodegenerative disorders known as neuronal ceroid lipofuscinoses (NCLs), which are characterized by the accumulation of lipofuscin-like autofluorescent storage materials in neurons and other cell types.

The study of CLN8 inhibitors is of significant interest in the field of molecular biology and neurodegenerative disorders research. By elucidating the impact of CLN8 inhibition, researchers aim to gain insights into the mechanisms underlying NCLs and the role of CLN8 in neuronal homeostasis and cellular processes related to protein processing and degradation. However, it is essential to underscore that the field of CLN8 Inhibitors is continuously evolving, and comprehensive investigations are necessary to fully elucidate the molecular mechanisms underlying the inhibition of CLN8. As with any area of active research, continued exploration of CLN8 inhibitors holds promise in advancing our understanding of the functions and implications of the CLN8 protein in neurodegenerative disorders, potentially leading to novel discoveries and future research directions in molecular biology and neuroscience. Nonetheless, until further data becomes available, the full extent of the implications and potential applications of CLN8 Inhibitors remains a topic for further exploration and scientific inquiry.

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A compound that can modulate the mTOR pathway, which is involved in cell growth and autophagy, and may have implications for CLN8-related cellular functions.

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