Date published: 2025-12-24

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CEP120 Inhibitors

Chemical inhibitors of CEP120 target its function, which is primarily associated with centriole assembly and microtubule organization within the cellular architecture. Paclitaxel (Taxol), for instance, stabilizes microtubules and inhibits their disassembly, which can disrupt CEP120's role in centriole assembly due to altered microtubule dynamics. Similarly, microtubule-destabilizing agents such as Nocodazole, Colchicine, Vinblastine, and Vincristine bind to tubulin or interfere with its polymerization, preventing proper microtubule formation. This inhibition of microtubule assembly can hinder the essential functions of CEP120, given its involvement in centrosome composition, by causing an imbalance in the microtubule network that CEP120 is meant to regulate. In addition to these, Podophyllotoxin and Eribulin affect microtubule dynamics, with Podophyllotoxin preventing assembly and Eribulin inhibiting the growth phase of microtubules without affecting the shortening phase. These actions can lead to the functional inhibition of CEP120 by altering the microtubule formation and stability that are crucial for its activity. Griseofulvin, Combretastatin A4, and Tivantinib also bind to tubulin but at different sites or affect its polymerization differently, which can result in the functional disruption of CEP120's role in microtubule-dependent processes. Noscapine alters the dynamics of microtubules, negatively affecting CEP120 function related to microtubule organization. Lastly, Peloruside A, like Paclitaxel, stabilizes microtubules, which can lead to the functional inhibition of CEP120 by affecting its role in centriole assembly and overall microtubule dynamics.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$40.00
$73.00
$217.00
$242.00
$724.00
$1196.00
39
(2)

Paclitaxel stabilizes microtubules and as such, can inhibit microtubule disassembly. CEP120 is involved in centriole assembly and microtubule organization. Stabilization of microtubules by Paclitaxel can disrupt CEP120's function in centriole assembly.

Nocodazole

31430-18-9sc-3518B
sc-3518
sc-3518C
sc-3518A
5 mg
10 mg
25 mg
50 mg
$58.00
$83.00
$140.00
$242.00
38
(2)

Nocodazole disrupts microtubule polymers, which can impair microtubule-dependent processes. CEP120, being essential for microtubule organization, can be functionally inhibited due to the disruption of microtubules by Nocodazole.

Colchicine

64-86-8sc-203005
sc-203005A
sc-203005B
sc-203005C
sc-203005D
sc-203005E
1 g
5 g
50 g
100 g
500 g
1 kg
$98.00
$315.00
$2244.00
$4396.00
$17850.00
$34068.00
3
(2)

Colchicine binds to tubulin, preventing its polymerization into microtubules, thereby inhibiting microtubule formation. CEP120's role in centrosome and microtubule organization can be impeded due to the lack of proper microtubule assembly.

Vinblastine

865-21-4sc-491749
sc-491749A
sc-491749B
sc-491749C
sc-491749D
10 mg
50 mg
100 mg
500 mg
1 g
$100.00
$230.00
$450.00
$1715.00
$2900.00
4
(0)

Vinblastine binds to tubulin, interfering with microtubule assembly. By inhibiting microtubule formation, Vinblastine can hinder CEP120's function related to the microtubule network and centriole stability.

Podophyllotoxin

518-28-5sc-204853
100 mg
$82.00
1
(1)

Podophyllotoxin inhibits microtubule assembly. By disrupting the normal function of microtubules, it can indirectly inhibit the function of CEP120 in centriole duplication and microtubule organization.

Eribulin

253128-41-5sc-507547
5 mg
$865.00
(0)

Eribulin inhibits the growth phase of microtubules without affecting the shortening phase. This selective inhibition can lead to the functional inhibition of CEP120 by altering the dynamics of microtubule formation and stability.

Griseofulvin

126-07-8sc-202171A
sc-202171
sc-202171B
5 mg
25 mg
100 mg
$83.00
$216.00
$586.00
4
(2)

Griseofulvin disrupts microtubule function by binding to tubulin, which can interfere with microtubule-dependent processes. CEP120's role in microtubule organization can be functionally inhibited as a result.

Combrestatin A4

117048-59-6sc-204697
sc-204697A
1 mg
5 mg
$45.00
$79.00
(0)

Combretastatin A4 binds to tubulin at the colchicine site and inhibits its polymerization. The resulting disturbance in microtubule dynamics can functionally inhibit CEP120, which is crucial for microtubule-related processes.

Noscapine

128-62-1sc-219418
10 mg
$102.00
(1)

Noscapine alters microtubule dynamics, which can negatively affect CEP120's function in microtubule organization due to disruption of normal microtubule function.

ARQ 197

905854-02-6sc-364408
sc-364408A
50 mg
200 mg
$712.00
$1920.00
(0)

Tivantinib is known to bind to tubulin and inhibit its polymerization. This action can functionally inhibit CEP120 by disrupting the microtubule network that is essential for its role in centrosome and centriole function.