CENP-N Inhibitors
Chemical inhibitors of CENP-N can function by targeting the microtubule dynamics that are essential for the protein's role in chromosome segregation during cell division. Vinblastine disrupts CENP-N function by binding to tubulin, thereby inhibiting microtubule assembly and indirectly hindering the ability of CENP-N to maintain proper chromosome alignment and segregation. Colchicine and Nocodazole further contribute to the inhibition of CENP-N by binding to tubulin subunits, preventing their polymerization, and leading to microtubule depolymerization, which is a state incompatible with the functions that CENP-N needs to fulfill during mitosis.
Furthermore, Podophyllotoxin and Griseofulvin indirectly inhibit CENP-N by compromising microtubule formation, which is crucial for the kinetochore function that CENP-N supports. Eribulin, with its unique mechanism of inhibiting microtubule growth without affecting shortening, leads to defective mitotic spindle formation, thus inhibiting CENP-N function in chromosome segregation. Thiabendazole, Albendazole, and Parbendazole, by disrupting microtubule polymerization, indirectly impair the function of CENP-N, which is integral to the mitotic spindle's interaction with chromosomes. Mebendazole's inhibition of tubulin polymerization negatively affects the microtubule-kinetochore complex, interfering with the role of CENP-N during mitosis. Lastly, Trifluralin, which interferes with microtubule assembly, can inhibit CENP-N's role in chromosome movement during cell division, further showcasing the interdependence of microtubule dynamics and CENP-N function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule assembly. Since CENP-N requires properly formed microtubules for chromosome segregation, Vinblastine's inhibition of microtubule polymerization can indirectly inhibit CENP-N function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and prevents its polymerization, leading to microtubule depolymerization. CENP-N, being essential for centromere function during mitosis, would be indirectly inhibited due to the disruption of microtubule structure and thus chromosome movement. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. The inhibition of microtubule dynamics by Nocodazole can indirectly inhibit CENP-N by impairing the attachment of microtubules to kinetochores, where CENP-N performs a crucial role. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization. By destabilizing microtubules, it can indirectly inhibit the function of CENP-N, which relies on microtubule interactions to fulfill its role in chromosome alignment and segregation. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, affecting mitotic spindle formation. This will indirectly inhibit CENP-N by impairing the microtubule-kinetochore interactions necessary for CENP-N to function during mitosis. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, leading to incomplete mitotic spindles. This can indirectly inhibit CENP-N, which is dependent on proper spindle microtubule dynamics to facilitate chromosome congression and segregation. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole interferes with microtubule polymerization. This disruption can indirectly inhibit CENP-N's function, as it requires proper microtubule formation for its role in chromosome alignment and segregation. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole causes degenerative alterations in the intestinal cells of helminths by binding to colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. This action can indirectly inhibit CENP-N because of its reliance on microtubule structures for proper function. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole disrupts microtubule synthesis by binding to tubulin, inhibiting its polymerization. Since CENP-N's function is closely associated with the microtubule-kinetochore complex during mitosis, disruption in microtubule assembly can indirectly inhibit CENP-N function. | ||||||