Cdc25C Activators
Common Cdc25C Activators include, but are not limited to Hydroxyurea CAS 127-07-1, Etoposide (VP-16) CAS 33419-42-0, Caffeine CAS 58-08-2, Fluorouracil CAS 51-21-8 and Doxorubicin hydrochloride CAS 25316-40-9.
Cdc25C activators belong to a class of chemical compounds that have a specific focus on a crucial regulatory protein known as Cdc25C. Cdc25C is a phosphatase enzyme that plays a pivotal role in cell cycle progression and cell division. It acts as a checkpoint regulator, ensuring the orderly transition of cells from the G2 phase to the M phase of the cell cycle. This transition is essential for the accurate replication and division of cells during growth and development. Cdc25C achieves its regulatory function by dephosphorylating target proteins, specifically those involved in mitosis, thereby promoting the entry of cells into the M phase.
Cdc25C activators are designed to modulate the activity of this enzyme. They typically work by enhancing the catalytic activity of Cdc25C, which in turn promotes the dephosphorylation of key substrates involved in cell cycle progression. The activation of Cdc25C is a tightly regulated process, and aberrant activation or inhibition of this enzyme can have significant implications for cell division and genome stability. Researchers are keenly interested in understanding the mechanisms and applications of Cdc25C activators in cellular biology, as they hold the key to unraveling the intricate control of cell cycle progression and may offer insights into areas such as cancer research and developmental biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea stalls DNA replication, inducing a cellular response that might increase Cdc25C levels to attempt to regulate the cell cycle checkpoint. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide induces DNA damage, potentially leading to enhanced Cdc25C expression as the cell attempts to overcome cell cycle arrest induced by the damage. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine affects multiple cellular pathways, including ATM and ATR kinases, which are involved in DNA damage responses. This might indirectly influence Cdc25C expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU disrupts DNA synthesis. Cells might upregulate Cdc25C in an attempt to regulate the cell cycle in response to this disruption. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin induces DNA damage, potentially leading to increased Cdc25C expression as part of the cellular response to the damage. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
By inhibiting DNA topoisomerase I, camptothecin leads to DNA breaks. This could elevate Cdc25C levels as cells attempt to overcome induced cell cycle checkpoints. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine inhibits CDKs. Cells might upregulate Cdc25C in response to the inhibition, attempting to balance cell cycle regulation. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $251.00 | 10 | |
UCN-01 inhibits checkpoint kinases. This might lead to increased Cdc25C expression as a compensatory mechanism to regulate cell cycle progression in the presence of DNA damage. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate disrupts DNA synthesis. Cells might elevate Cdc25C levels in an attempt to regulate the cell cycle in response to this disruption. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin inhibits DNA polymerase, stalling DNA replication. This might lead to enhanced Cdc25C expression as cells try to manage the cell cycle arrest. | ||||||